C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene. [5] . Two ligands have been identified for this receptor: the chemokines (C-C motif) ligand 19 (CCL19 /ELC) and (C-C motif) ligand 21 (CCL21). [6] .

Recent evidence suggests that by guiding cells to and within lymphoid organs, CC-chemokine receptor 7 (CCR7) essentially contributes to both immunity and tolerance.

Growing evidence suggests that cell trafficking orchestrated by the C-C chemokine receptor 7 (CCR7) plays a critical role in the pathophysiology of several leukemias and lymphomas.

Chemokine receptors promote chemotaxis of cells and tissue organization. Since under homeostatic conditions, CCR7 promotes migration of immune cells to lymph nodes, questions immediately arose regarding the ability of CCR7 to direct migration of …

2024年12月24日 · CCR7 (C-C Motif Chemokine Receptor 7) is a Protein Coding gene. Diseases associated with CCR7 include Chronic Graft Versus Host Disease and Pars Planitis. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

In the present study, we investigated the role of CCR7 in the pathogenesis of collagen-induced arthritis (CIA). By using a novel anti-human CCR7 antibody and humanized CCR7 mice, we evaluated CCR7 as a target in this autoimmune model of rheumatoid arthritis (RA).

2017年8月17日 · Our study indicates that CCR7 homodimerization critically regulates CCR7 ligand-dependent cell migration and intracellular signaling in multiple cell types. Recruitment of lymphocytes from the...