CCR2 is a CC chemokine receptor. This CCR2 gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [5] This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1 (CCL2), a chemokine which specifically mediates monocyte chemotaxis.

2024年12月24日 · CCR2 (C-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include Polycystic Lung Disease and Human Immunodeficiency Virus Type 1. Among its related pathways are Class A/1 (Rhodopsin …

RESULTS: CCR2 PET revealed significantly higher radiotracer uptake in both Apoe−/− and Ldlr−/− mice treated with anti-PD1 compared with the control groups. The increased expression of CCR2+ cells in Apoe−/− and Ldlr−/− mice was confirmed by immunostaining and flow cytometry.

2023年1月31日 · As a G protein–coupled receptor (GPCR), CCR2 promotes monocyte migration in response to the chemokine CCL2. As a scavenger receptor for CCL2, CCR2 sequesters CCL2 intracellularly to regulate its extracellular concentration.

2023年9月1日 · C–C motif chemokine receptor 2 (CCR2), together with its ligands, especially C–C motif ligand 2 (CCL2), to which CCR2 has the highest affinity, form a noteworthy signaling pathway in recruiting macrophages for the immune responses among variegated disorders in …

Macrophages play a critical role in the establishment of a regulated inflammatory response following tissue injury. Following injury, CCR2+ monocytes are recruited from peripheral blood to wound tissue, and direct the initiation and resolution of ...

CCR2 refers to a receptor that plays a crucial role in attracting monocytes and macrophages in the context of COPD. Blocking CCR2 has the potential to be a therapeutic strategy for this condition. You might find these chapters and articles relevant to this topic.

2022年2月24日 · The CCL2-CCR2 axis is currently the most well-studied chemokine pathway in liver disease. CCR2 and its ligands have become therapeutic targets of interest for biopharmaceutical companies. Among them, CVC is an orally …

2022年7月18日 · We showed that CCR2 overexpression was an independent prognostic marker and predicted shorter overall survival (OS) and progression-free survival (PFS) in patients with DLBCL.

2025年2月8日 · Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase.