G1/S-specific cyclin-D2 is a protein that in humans is encoded by the CCND2 gene. [5] The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of cyclin-dependent kinases.

2024年12月24日 · CCND2 (Cyclin D2) is a Protein Coding gene. Diseases associated with CCND2 include Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 3 and Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 .

The CCND2 gene provides instructions for making a protein called cyclin D2. Learn about this gene and related health conditions.

CCND2 can be exploited as a novel prognostic biomarker involved in immune infiltration of LUAD, hence providing new preventative and therapeutic options for LUAD. Keywords: CCND2, lung adenocarcinoma (LUAD), immune infiltration, prognosis

2025年1月4日 · Title: CCND2 and miR-206 as potential biomarkers in the clinical diagnosis of thyroid carcinoma by fine-needle aspiration cytology. LncRNA RP11805J14.5 functions as a ceRNA to regulate CCND2 by sponging miR34b3p and miR1395p in lung adenocarcinoma.

2018年1月5日 · CCND2 overexpression activates cell cycle progression in hiPSC-CMs that results in a significant enhanced potency for myocardial repair as evidenced by remuscularization of injured myocardium. This left ventricular muscle regeneration and increased angiogenesis in border zone are accompanied by a si …

2025年2月8日 · CCND2 was identified as a putative target gene for SMYD3 transcriptional regulation, through trimethylation of H4K20.Our results support a proto-oncogenic role for SMYD3 in prostate carcinogenesis, mainly due to its methyltransferase enzymatic activity.

2020年9月3日 · HGNC Approved Gene Symbol: CCND2. Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38) : 12:4,273,762-4,305,353 (from NCBI) Inaba et al. (1992) used murine cDNA clones for 3 cyclin D genes that are normally expressed during the G1 phase of the cell cycle to clone the cognate human genes.

2025年1月4日 · Clinical resource with information about CCND2, Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies., Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval., Genome-wide association ...

Here we report that individuals with MPPH lacking upstream PI3K-AKT pathway mutations carry de novo mutations in CCND2 (encoding cyclin D2) that are clustered around a residue that can be phosphorylated by glycogen synthase kinase 3β (GSK-3β).