2024年12月24日 · CCNB1 (Cyclin B1) is a Protein Coding gene. Diseases associated with CCNB1 include Tongue Carcinoma and Laryngeal Squamous Cell Carcinoma. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Loss of proteins required for interphase microtubule organization from the centrosome.

Cyclin B1 is a regulatory protein involved in mitosis. The gene product complexes with p34 (Cdk1) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript that is expressed predominantly during G2/M phase of the cell cycle.

2023年9月27日 · Through this work, we performed a pancancer analysis of the levels of CCNB1 and dissected aspects of regulation and how this correlates with cancer prognosis. We comprehensively evaluated the...

该基因编码的蛋白质是一种参与有丝分裂的调节蛋白。 基因产物与 p34 (cdc2) 复合形成成熟促进因子 (MPF) 。 编码的蛋白质对于正确控制细胞周期的 G2/M 过渡阶段是必需的。 [RefSeq 提供，2017 年 8 月] The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34 (cdc2) to form the maturation-promoting factor (MPF).

2025年2月8日 · CCNB1 is a biomarker for the prognosis of ER+ breast cancer and monitoring of hormone therapy efficacy; that CCNB1 contained many CD4 T cell epitopes, which are differentially recognized by pre-existing naive and memory CD4 T cells. CCNB1 activation is associated with recurrence in non-muscle-invasive bladder cancer.

2020年8月31日 · We aimed to comprehensively investigate the roles of CDK1, CCNB1, and CCNB2 via multi-omics analysis and their relationships with immune infiltration in hepatocellular carcinoma (HCC).

摘要 : 细胞周期蛋白B1 (cyclin B1， CCNB1)是有丝分裂期(M期)周期蛋白， 与细胞周期蛋白依赖性激酶1 (cyclin-dependent kinase 1， CDK1)结合形成成熟促进因子(maturation promoting factor， MPF)， MPF的激活为真核细胞启动有丝分裂所必需。

2023年8月17日 · CCNB1 silencing significantly inhibited the proliferation, migration, and invasive capabilities of WIT-49 cells, also, promoted apoptosis, and in turn induced G2 phase cell cycle arrest in loss-of-function assays.

CCNB1 was knocked-down by lentiviral-mediated infection of short hairpin RNA (shRNA) in GH3 and MMQ cell lines. The proliferation, cell cycle and apoptosis of GH3 and MMQ cell lines were detected using a Cell Counting Kit-8 and flow cytometer.

2025年3月7日 · Cyclin-dependent kinase 1 (CDK1) is the pivotal kinase responsible for initiating cell division. Its activation is dependent on binding to regulatory cyclins, such as CCNB1. Our research ...