Dec 24, 2024 · CCL22 (C-C Motif Chemokine Ligand 22) is a Protein Coding gene. Diseases associated with CCL22 include Eosinophilic Pneumonia and Dermatitis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include chemokine activity.

CCL22 controls T cell immunity, both by recruiting T regs to the tumor tissue and by promoting the formation of DC-T reg contacts in the lymph node. Here, we review the current knowledge on the role of CCL22 in cancer immunity.

Studying a newly established CCL22-deficient mouse, we demonstrate that CCL22 expression by dendritic cells (DCs) promotes the formation of cell–cell contacts and interaction with regulatory T cells (T reg) through their CCR4 receptor.

May 6, 2019 · Studying a newly established CCL22-deficient mouse, we demonstrate that CCL22 expression by dendritic cells (DCs) promotes the formation of cell-cell contacts and interaction with regulatory T cells (T reg) through their CCR4 receptor.

CCL22 could be an immune marker in ANCA-associated vasculitis. Suggest that lower CCL22 levels may play an important role in the pathogenesis of multiple sclerosis in women. CCL22 is an antimicrobial protein with bacteriocidal activity against E. coli and S. aureus.

CCL22 is a macrophage-derived chemokine [36] but is also produced by cancer cells, dendritic cells (DC), and tumor-associated macrophages (TAM) [37–41]. It can recruit regulatory T cells (Tregs) into tumor tissues and enhance tumor immune escape mechanisms.

Macrophage-derived chemokine (MDC, CCL22) is a member of the CC-chemokine family and is composed of 69 amino acid residues. MDC is mainly produced by macrophages and dendritic cells upon the stimulation with microbial products, or anti-CD40 antibody, and is upregulated by TH2-type cytokines, such as …

C–C chemokine ligand 22 (CCL22), also known as Macrophage-derived chemokine (MDC), is expressed in dendritic cells, macrophages, and activated monocytes . Mature CCL22 induces chemotaxis or Ca 2+ activation in NK cells, activated T lymphocytes and dendritic cells .

Jun 26, 2024 · Here, we show that local LN removal within inguinal white adipose tissue (iWAT) greatly impairs cold-induced beiging, and this impairment can be restored by injecting M2 macrophages or macrophage-derived C-C motif chemokine (CCL22) into iWAT.

Nov 21, 2023 · We report here that cytosolic dsDNA introduced into malignant cells can robustly upregulate expression of CCL22, a chemokine responsible for the recruitment of regulatory T cells (Tregs). Tregs...