Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta).

CCL19 modulates tumor immune microenvironment features and predicts prognosis in breast cancer patients. (A) We implemented with the CIBERSORT algorithms and identified prominently positive association between CCL19 expression and tumor-associated immune cells, including B cells, CD4+ T cells, CD8+ T cells, neutrophil, and myeloid dendritic cells.

Here, we focus on the cellular and molecular mechanisms that enable CCR7 and its two ligands, CCL19 and CCL21, to balance immunity and tolerance.

2024年12月24日 · CCL19 (C-C Motif Chemokine Ligand 19) is a Protein Coding gene. Diseases associated with CCL19 include Allergic Contact Dermatitis and Polyradiculoneuropathy. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway.

CCL19 is located in the extrafollicular region, while CCL21 is restricted to lymphatic vessels [73]. IFN-γ induction and CCL21 overexpression lead to the release of chemokines CXCL9 and CXCL10. This translates into an anti-tumor response by inhibiting angiogenesis.

2023年11月8日 · Background: CCL19 is a chemokine involved in cancer research due to its important role in the tumor microenvironment (TME) and clinical relevance in cancers. This study aimed to analyze transcription expression, genomic alteration, association with tumor immune microenvironment of CCL19 expression and its prediction value for prognosis and ...

Chemokine (C–C motif) ligand 19 (CCL19) is a critical regulator of the induction of T cell activation, immune tolerance, and inflammatory responses during continuous immune surveillance, homeostasis, and development.

2024年8月12日 · We identify a fibroblast lineage secreting CCL19 that facilitates lymphocyte trafficking to TLSs. CCL19 treatment promotes TLS neogenesis and prevents tumor growth in mice. Our data uncover the central role of CCL19 + fibroblasts in TLS formation, which in turn generates therapeutic antibodies to restrict CRLM.

2021年12月28日 · Through the induction of anti-tumor immune responses and inhibition of angiogenesis, CCL19 exerts tumor-suppressive functions. In contrast, CCL19 also acts as a tumor-supportive factor by inducing inflammation, cell growth, and metastasis.

Chemokine (C–C motif) ligand 19 (CCL19) is a critical regulator of the induction of T cell activation, immune tolerance, and inflammatory responses during continuous immune surveillance, homeostasis, and development.