Dec 24, 2024 · CBX3 (Chromobox 3) is a Protein Coding gene. Diseases associated with CBX3 include Hyperoxaluria, Primary, Type I and Hutchinson-Gilford Progeria Syndrome. Among its related pathways are RNA Polymerase I Promoter Opening and Gene expression (Transcription).

Aug 26, 2023 · Here we describe that a wide spectrum of human cancers harbors a co-amplification of CBX3 gene with either EGFR or RAC1, which yields a statistically significant increase of both mRNA and protein...

Apr 22, 2022 · Briefly, we found that, CBX3 is significantly upregulated in GBM and reduces patient survival. In addition, functional assays demonstrated that CBX3 significantly promote the proliferation,...

May 23, 2024 · Here, we demonstrate that chromobox protein homolog 3 (CBX3) binds replication protein A 32-kDa subunit (RPA2) and regulates RPA2 retention at stalled replication forks. CBX3 is recruited to stalled replication forks by RPA2 and inhibits ring finger and WD repeat domain 3 (RFWD3)–facilitated replication restart.

Genome-wide localization analysis reveals CBX3 binding at genic regions, which strongly correlates with gene activity across multiple cell types. Depletion of CBX3 resulted in down-regulation of a subset of target genes. Loss of CBX3 binding leads to a more dramatic accumulation of unspliced nascent transcripts.

Apr 14, 2011 · Genome-wide localization analysis reveals CBX3 binding at genic regions, which strongly correlates with gene activity across multiple cell types. Depletion of CBX3 resulted in down-regulation of a subset of target genes. Loss of CBX3 binding leads to a more dramatic accumulation of unspliced nascent transcripts.

Jan 5, 2025 · Title: CBX3 promotes breast cancer progression and high level of CBX3 predicts poor prognosis in patients. The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis.

3 days ago · CBX3 overexpression increased Irinotecan and Oxaliplatin resistance, whereas CBX3 knockdown suppressed multidrug resistance in CRC cells. Additionally, CBX3 inhibited ferroptosis associated with ...

Feb 9, 2025 · Identification of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma. Loss of CBX3 results in global RNA processing defect. The Cbx3 chromodomain binds with comparable affinities to all of the methylated H3K9, H1K26 and G9aK185 peptides.

Aug 30, 2024 · We analyze the main upstream regulators of CBX3 expression and activity and describe the various pathways involving CBX3, highlighting its differential mechanisms of action as well as its significance as a potential therapeutic biomarker in lung cancer.