2024年12月24日 · CASP3 (Caspase 3) is a Protein Coding gene. Diseases associated with CASP3 include Spinal Cord Injury and Ischemia . Among its related pathways are TNFR1 Pathway and Apoptosis and survival FAS signaling cascades .

Caspase-3, a cysteine-aspartic acid protease, has recently attracted much attention because of its incredible roles in tissue differentiation, regeneration, and neural development. This enzyme is a key zymogen in cell apoptosis and is not activated until it …

CASP3 is the gene encoding caspase-3, a specific protease that cleaves substrates such as poly-ADP ribose polymerase and acetyl-DEVD-7-amino-4-methylcoumarin. This enzymatic activity leads to DNA fragmentation, which is a hallmark of apoptosis.

Caspase-3 is a cysteine-aspartic protease that plays a key role in the process of apoptosis and is widely used as a biomarker for apoptosis. During apoptosis, Caspase-3 is cleaved into two fragments with molecular weights of 17 kDa (p17) and …

2025年2月9日 · Title: CASP3 gene expression and the role of caspase 3 in the pathogenesis of depressive disorders. Evaluation of the Expression of miRNAs, LncRNAs, and their Target Gene, Caspase 3 in Glioblastoma Multiform: A Case-Control Study.

2024年2月6日 · Caspase-3 (CASP3) has long been recognized for its proteolytic role in orchestrating cell death-initiated pathways and related processes; however, whether CASP3 has other functions in mammalian...

2025年2月9日 · CASP3 gene is up-regulated in LNCaP and PC-3 prostate cancer cell lines. Rabbit antithymocyte globulin facilitates apoptosis of alloreactive T cells by means of caspase-3 activation, which may explain its steroid-sparing effect in pediatric liver and intestine recipients.

2018年8月15日 · Caspase-3 (CASP3) is a major mediator of apoptosis activated during cellular exposure to cytotoxic drugs, radiotherapy or immunotherapy. It is often used as a marker for efficacy of cancer therapy. However, recent reports indicate that caspase-3 has also non-apoptotic roles such as promotion of tumo …

CASP3; caspase 3: Aliases: CPP32, SCA-1, CPP32B : Location: 4q35.1: Summary: The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis.

Cysteinyl aspartate-specific proteases, or caspases, such as CASP3, cleave substrates directly after an aspartic acid residue and play essential roles in programmed cell death. Caspases are synthesized in a dormant form with an N-terminal prodomain followed by …