Dec 24, 2024 · CASP1 (Caspase 1) is a Protein Coding gene. Diseases associated with CASP1 include Cowpox and Shigellosis. Among its related pathways are Inflammasomes and Gene expression (Transcription). Gene Ontology (GO) annotations related to this gene include peptidase activity and cysteine-type peptidase activity. An important paralog of this gene is …

Caspase-1 /Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides. [5][6][7] It plays a central role in cell immunity a...

Feb 9, 2025 · Force-induced Caspase-1-dependent pyroptosis regulates orthodontic tooth movement.

该基因通过蛋白水解切割和激活白细胞介素-1 的无活性前体的能力得到鉴定，白细胞介素-1 是一种参与炎症、感染性休克和伤口愈合等过程的细胞因子。 该基因已被证明可诱导细胞凋亡，并可能在各个发育阶段发挥作用。 对小鼠中相似基因的研究表明它在亨廷顿病的发病机制中起作用。 可变剪接导致编码不同亚型的转录变体。 [RefSeq 提供，2012 年 3 月] This gene encodes a protein which is a member of the cysteine-aspartic acid protease (Caspase) family.

Mar 27, 2017 · Caspase-1, also known as interleukin-1β (IL-1β)-converting enzyme (ICE), regulates antimicrobial host defense, tissue repair, tumorigenesis, metabolism and membrane biogenesis. On activation within...

Caspase-1 也可称为IL-1β 转换酶, 其基因位于人染色体的11q22-q23 区, 它的基因全长cDNA于1992 年被成功克隆[3] 。 未成熟的caspase-1 mRNA含有10 个外显子, 通过可变剪切、转录翻译成6种不同的亚型: α、β、γ、δ、ε、ζ 。这六种caspase-1亚型除了皆能介导炎症反应, 还可在细胞死亡中发挥不同的作用: 其中α、β、γ 和ζ能有效介导细胞死亡, δ 则无此效应;而ε 与细胞存活呈正相 …

Dec 20, 2024 · 本文基于美国杜克大学医学院研究者在Nature上发表的最新研究“Caspase-7 activates ASM to repair gasdermin and perforin pores”，旨在深入探讨Caspase-1在细胞死亡与免疫防御中的多功能角色。 Caspase-1，也被称为白细胞介素-1β转换酶（IL-1β-converting enzyme, ICE），是Caspase家族中的关键成员之一。 它主要存在于细胞质中，并在炎症反应中扮演核心角色。 当细胞受到病原体感染或损伤时，Caspase-1会被激活，进而切割并激活IL-1β和IL-18等 …

Feb 9, 2025 · The NLRP3-CASP1 inflammasome modulates cellular levels of the glucocorticoid receptor and diminishes cell sensitivity to glucocorticoids. The relative level of aortic caspase-1 expression was elevated in patients who were smokers or with hypertension or diabetes.

Jul 12, 2024 · Caspase-1 is one of the main mediators of inflammatory caspases and has become a correspondent with inflammation and cell death. In cell death, caspase-1 was originally found to cause apoptosis in fibroblasts.

caspases以不活跃的前酶形式存在，在保守的天冬氨酸残基处经过蛋白水解加工，产生两个亚基，大亚基和小亚基，它们二聚形成活性酶。 这个基因通过其蛋白水解切割和激活白细胞介素-1的前体的能力而被鉴定，白细胞介素-1是一种参与炎症、败血性休克和伤口愈合等过程的细胞因子。 这个基因已被证明能诱导细胞凋亡，并在各种发育阶段中发挥作用。 研究小鼠中类似基因表明，它在亨廷顿病的病理发生中起作用。 可变剪接导致编码不同异质体的转录变异体。 …