Dec 24, 2024 · CA14 (Carbonic Anhydrase 14) is a Protein Coding gene. Diseases associated with CA14 include Intracranial Hypertension, Idiopathic and Mixed Sleep Apnea . Among its related pathways are Metabolism and Reversible hydration of carbon dioxide .

Carbonic anhydrase 14 is an enzyme that in humans is encoded by the CA14 gene. [5][6] Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide.

Data indicate that carbonic anhydrase isoform XIV (hCA XIV) shows high sequence identity with the other membrane-associated carbonic anhydrases (hCAs). Title: The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors.

CA14 is not prognostic Cancer specificity i Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected.

The full-length CA14 cDNA encodes a deduced 337-amino acid protein that shows 29 to 46% sequence similarity to other active CAs, with the highest similarity to CA12 (603263). CA14 is a type I transmembrane protein, with a putative N-terminal signal sequence and a C-terminal transmembrane domain.

Sep 17, 2024 · Clinical resource with information about CA14, Biological insights from 108 schizophrenia-associated genetic loci., and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Reversible hydration of carbon dioxide. Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt). Showing features for active site, binding site. Search…

Feb 8, 2025 · Data indicate that carbonic anhydrase isoform XIV (hCA XIV) shows high sequence identity with the other membrane-associated carbonic anhydrases (hCAs). Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

High impact information on CA14; Biological context of CA14; Anatomical context of CA14; Associations of CA14 with chemical compounds; Other interactions of CA14; Analytical, diagnostic and therapeutic context of CA14

Carbonic anhydrase 14 (CA14) is an enzyme encoded by the CA14 gene in humans. CA14 is part of a large family of zinc metalloenzymes called carbonic anhydrases (CAs) that catalyze the reversible hydration of carbon dioxide.