Carbonic anhydrase 12 is an enzyme that in humans is encoded by the CA12 gene. [5][6] Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide.

2024年12月24日 · CA12 (Carbonic Anhydrase 12) is a Protein Coding gene. Diseases associated with CA12 include Hyperchlorhidrosis, Isolated and Intracranial Hypertension, Idiopathic . Among its related pathways are Metabolism and Translational Control .

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2025年2月8日 · CA12 may be used as a novel prognostic marker in combination with histologic grade of invasive cervical cancer. our results imply that CA2 and CA12 are highly over-expressed in advanced atherosclerosis by osteoclast-like cells of monocytic origin

The CA12 gene provides instructions for making a protein called carbonic anhydrase 12 (CA 12), which belongs to a family of proteins known as carbonic anhydrases. Learn about this gene and related health conditions.

Higher expression of CAXII in breast cancer is indicative of lower grade disease. CAXII plays a key role in several physiological functions. Mutation in the CAXII gene causes cystic fibrosis-like syndrome and salt wasting disease. CAXII is also seen in nuclear pulposus cells of the vertebrae.

Carbonic anhydrase XII (CA12) is the key carbonic anhydrase in epithelial fluid and HCO 3 − secretion and works by activating the ductal Cl − –HCO 3 − exchanger AE2. Delivery of CA12 to salivary glands increases salivation in mice and of the …

The metabolic enzyme carbonic anhydrase 12 (CA12/CAXII) emerges as a promising cancer therapeutic target with drug development projects underway. Previous reports proposed the relevance of CA12 in the context of glioma but are limited in patient ...

2008年5月1日 · The expression of carbonic anhydrase XII (CA12), a gene that encodes a zinc metalloenzyme responsible for acidification of the microenvironment of cancer cells, is highly correlated with estrogen receptor alpha (ER alpha) in human breast tumors.