Dec 24, 2024 · C3AR1 (Complement C3a Receptor 1) is a Protein Coding gene. Diseases associated with C3AR1 include Atypical Hemolytic-Uremic Syndrome and Prostate Cancer. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and Complement cascade.

The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system. [5] [6] The receptor binds to complement component C3a, although there is limited evidence that this receptor also binds C4a in lesser mammals. This has yet to be proven true in humans. [7]

The complement C3a receptor 1 (C3aR1) has been extensively studied for its physiological role in C3a-mediated anaphylaxis/inflammation, and in TLQP-21-mediated lipolysis, but direct evidence for the functional relevance of the C3a and TLQP-21 …

C3a 是一种在补体系统激活过程中释放的过敏毒素。 该基因编码的蛋白质是 C3a 的孤儿 G 蛋白偶联受体。 编码受体与 C3a 的结合激活趋化性、颗粒酶释放、超氧阴离子产生和细菌调理作用。 [RefSeq 提供，2016 年 5 月] C3a is an anaphylatoxin released during activation of the Complement System. The protein encoded by this gene …

May 11, 2023 · These structures, combined with mutagenesis analysis, reveal a conserved recognition pattern of anaphylatoxins to the complement receptors that is different from chemokine receptors, unique pocket...

Feb 8, 2025 · High C3aR1 expression is associated with acute myeloid leukemia-M2. these findings suggest a critical role for C3a through autocrine/paracrine induction of C3aR in the pathogenesis of cigarette smoke-induced sterile inflammation and provide new therapeutic targets for the treatment of emphysema.

Jul 20, 2023 · In this study, we aim to characterize C3aR1 coupling preferences and investigate ligand-mediated C3aR1 signaling bias using endogenous agonists and other available C3aR1 ligands including the purported C3aR1 antagonist SB290157.

Feb 8, 2025 · Title: Molecular signatures of intrarenal complement receptors C3AR1 and C5AR1 correlate with renal outcome in human lupus nephritis. The Complement C3a-C3a Receptor Axis Regulates Epithelial-to-Mesenchymal Transition by Activating the ERK Pathway in Pancreatic Ductal Adenocarcinoma.

Activation of C3aR and C5aR1 was determined using DiscoverX beta-arrestin assays. Insulin secretion from human and mouse islets was measured by radioimmunoassay, and intracellular calcium ( [Ca 2+]i), ATP generation and apoptosis were assessed by standard techniques.

Dec 8, 2023 · 本研究表征了C3aR1作为Gi/o/z偶联受体，并证明了配体介导的信号偏向性在关键细胞模型中的功能相关性。 由于C3aR1及其内源性配体被认为与炎症和代谢性疾病有关，这些结果对未来的C3aR1药物研发具有重要意义。