Corynebacterium glutamicum - an overview | ScienceDirect Topics
Corynebacterium glutamicum (C. glutamicum) has been used for decades as the major producer of amino acids in industrial biotechnology. In the past years, substantial progress has been achieved of understanding fundamental knowledge about its gene expression and regulation, protein secretion, metabolism, and physiology, which enables engineering ...
Revealing Corynebacterium glutamicum proteoforms through …
2023年2月14日 · The present study describes the characterization of C. glutamicum proteoforms, and their post-translational modifications (PTMs) employing top-down proteomics.
Industrial production of L-lysine in Corynebacterium glutamicum ...
2022年9月1日 · C. glutamicum ASTALYS co-produces astaxanthin and L-lysine (titers of 10 mg/L, 48.2 g/L) in a 20 L fed-batch fermentation. This method has advantages in improving substrate utilization, reducing production costs and improving production efficiency.
Improved polyketide production in C. glutamicum by preventing …
2023年7月13日 · Here we provide evidence that accumulation of propionyl-CoA and methylmalonyl-CoA induces growth inhibition in C. glutamicum. We then show that growth inhibition can be relieved by introducing...
Advances in metabolic engineering of Corynebacterium glutamicum …
C. glutamicum has emerged as a potent host to produce molecules for human health and well-being, and has greatly expanded its role from a traditional producer of amino acids, chemicals, and materials to a multi-functional microbial production platform.
A manually curated compendium of expression profiles for the …
2022年10月1日 · The compendium provides a valuable resource for future fundamental and applied research with C. glutamicum and contributes to a systemic understanding of this microbial cell factory.
Corynebacterium glutamicum as a Host for Synthesis and Export …
Corynebacterium glutamicum is well known for its extraordinary l -amino acid production properties. Its most prominent feature is probably its capacity to produce l -glutamate, 1.8 million tons of which are currently produced per year and used as a sodium salt to be added to food (24).
Corynebacterium glutamicum as an Efficient Omnivorous …
2022年4月1日 · We demonstrated C. glutamicum as an efficient microbial host for utilizing diverse carbon substrates present in biomass hydrolysates, such as glucose, arabinose, and xylose, in addition to its natural ability to assimilate lignin-derived aromatics.
Corynebacterium glutamicum as a robust microbial factory for production ...
2021年1月1日 · C. glutamicum is a Gram-positive bacterium with its discovery traced back to the post-World War II period in Japan, during which high cost of (l-glutamate production through chemical decomposition simulated the development of a microbial process to produce this amino acid (Udaka, 2008).
The Industrial Organism Corynebacterium glutamicum Requires …
2020年10月9日 · In aerobic bioreactor cultivations, C. glutamicum becomes exposed to oxygen concentrations surpassing the air saturation, which are supposed to constitute a challenge for the intracellular MSH redox balance. In this study, the role of MSH was investigated at different oxygen levels (pO 2) in bioreactor cultivations in C. glutamicum.
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