Small intestine: chromogranin c-kit / CD117 DOG1 Ki67 synaptophysin Stomach: chromogranin c-kit / CD117 claudin 18.2 (pending) DOG1 desmin EBER1 / 2 / LMP gastrin (pending) Helicobacter pylori HER2 stomach GEJ INSM1 Ki67 S100 SMA synaptophysin Warthin-Starry GU / adrenal Adrenal: calretinin chromogranin CK7 GATA3 GD2 (pending) inhibin MelanA ...

Mar 11, 2025 · KIT is the gene encoding a transmembrane tyrosine kinase receptor, involved in both the MAP kinase and AKT pathways, which are intimately involved with cell proliferation and survival (J Clin Oncol 2013;31:3176, Int J Biol Sci 2013;9:435)

Sep 21, 2020 · Well circumscribed lesion; usually no pseudocapsule, tumor directly abuts the renal parenchyma (Am J Surg Pathol 1997;21:1, J Kidney Cancer VHL 2017;4:1)

Sep 2, 2021 · Monoclonal (SP31, K9, DOG1.1) and polyclonal antibodies (Cancer Control 2015;22:498) Most sensitive and specific marker for GIST

May 24, 2022 · Unfavorable prognostic features: Clinical: ↑ age, ↑ LDH, Eastern Cooperative Oncology Group (ECOG) ≥ 2, Ann Arbor stage III / IV, extranodal disease, bulky disease (J Clin Oncol 2010;28:2373, Blood 2014;123:837)

Feb 16, 2022 · However, due to the lack of sensitivity and specificity and emerging utility for PAX8, CAIX, CK7 and CD117 (c-kit), RCC has become less commonly used by pathologists (Histopathology 2020;77:659 Hum Pathol 2021 May 4 [Epub ahead of print])

Apr 16, 2024 · Primary cutaneous adenoid cystic carcinoma (PCACC) is a rare adnexal tumor with different histopathologic growth patterns, including cribriform, tubular and solid variants

Dec 17, 2024 · PAX8 (100%) ; TFE3 (95%) . Very high sensitivity; positive in 95% of cases Should be used with cautious interpretation given that it can be overexpressed in other tumor types that do not harbor a TFE3 rearrangement, including epithelioid angiomyolipoma (AML), paragangliomas, adrenocortical carcinomas, melanomas and others (Adv Anat Pathol …

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However, GISTs are uniformly c-kit positive and usually CD34 positive. The differential diagnosis also includes fibroblastic reticulum cell sarcoma (vimentin+, smooth muscle actin+, desmin+, CD21-, CD35-), interdigitating dendritic cell tumor (S100+, vimentin+, CD21-, CD35-), melanoma or other sarcomas.