Bromodomain-containing protein 9 is a protein that in humans is encoded by the BRD9 gene. [1] BRD9 contains a bromodomain. It is closely related to BRD7. BRD9 is present in some SWI/SNF ATPase remodeling complexes. [2] The BRD9 gene is frequently present in variable copy number in lung cancer. [3]

2024年12月24日 · BRD9 (Bromodomain Containing 9) is a Protein Coding gene. Diseases associated with BRD9 include Sarcoma and Rhabdoid Cancer. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and lysine-acetylated histone binding. An important paralog of this gene is BRD7.

2022年11月15日 · In summary, our data identify a novel function for BRD9 in promoting ribosome biogenesis in MM. BRD9 depletion impairs ncBAF localization to its genomic targets, thereby disrupting ribosome biogenesis machinery, resulting in significant cell growth inhibition.

Bromodomain-containing protein 9 (BRD9) is a component of the ncBAF chromatin remodeling complex and has been recently indicated as a strong dependency in AML (Weisberg et al 2022). It has been shown that inhibitors of BRD9 induce growth inhibition and expression of …

BRD9 is a prognostic marker in Bladder urothelial carcinoma, Glioblastoma multiforme, Liver hepatocellular carcinoma, Ovary serous cystadenocarcinoma

2021年2月15日 · Here, we show that GBAF, particularly its BRD9 subunit, is required for the viability of prostate cancer cell lines in vitro and for optimal xenograft tumor growth in vivo. BRD9 interacts with androgen receptor (AR) and CCCTC-binding factor (CTCF), and modulates AR-dependent gene expression.

2022年11月15日 · Bromodomain-containing protein 9 (BRD9) functions as a key component of the chromatin remodeling complex in regulation of gene transcription, which is widely implicated in tumorigenicity.

2024年7月25日 · BRD9 is thought to be a key player in chromatin remodeling and gene expression regulation. Inhibition of BRD9 activity plays an important role in the treatment of certain cancers, making it a potential target for anticancer drugs.

2024年3月28日 · Bromodomain-containing protein 9 (BRD9) has been shown to be important for the survival of MM cells. We discovered that drugs that block the function of BRD9 increase the effectiveness of IMiDs and can override resistance to these medications.

2021年11月26日 · Inhibition of bromodomain-containing protein 9 (BRD9), a subunit of the ncBAF complex, with BRD9 bromodomain inhibitors (BRD9i) or a degrader (dBRD9), led to reduction in a number of interferon-stimulated genes (ISGs) following stimulation with endotoxin lipid A. BRD9-dependent genes overlapped highly with a subset of genes differentially ...