Benzo (a)pyrene-7,8-diol-9,10-epoxide (BPDE) is a highly reactive DNA damage agent and can induce cell death through both p53-independent and -dependent pathways. However, little is …

Within the present study, we applied the reactive metabolite benzo [a]pyrene diolepoxide (BPDE) in the nanomolar, non-cytotoxic concentration range in human TK6 cells and quantified the …

Within the present study, we applied the reactive metabolite benzo [a]pyrene diolepoxide (BPDE) in the nanomolar, non-cytotoxic concentration range in human TK6 cells and quantified the …

Benzo(a)pyrene (B[a]P) and its ultimate active metabolite, benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE), are known to have neurotoxic effects that can damage hippocampal neurons …

Nov 2, 2016 · Carcinogenicity of benzo [a]pyrene {B [a]P, a polycyclic aromatic hydrocarbon (PAH)} involves DNA-modification by B [a]P diol epoxide (BPDE) metabolites. Adducts to …

Mar 4, 1997 · Alkylation of DNA by 7r,8t-dihydroxy,9t,10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE) forms mainly trans adducts (with respect to the C-9/10 …

Nov 10, 2024 · In the body, BaP is enzymatically converted to form a more active benzo (a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE). BaP/BPDE has the potential to trigger gene …

We evaluated the levels of BPDE-DNA adducts, lnc-HZ09, and the mRNA and protein expression of members of the PLD1/RAC1/CDC42 pathway, and correlated their relative expression levels.

Apr 1, 2003 · Benzo (a)pyrene diol epoxide (BPDE), an active metabolite of the tobacco carcinogen benzo (a)pyrene, can induce p53 gene mutation, down-regulate retinoic acid …

Mar 10, 2021 · BPDE is the carcinogenic metabolite of B[a]P produced through cytochrome P450 and epoxide hydrolase catalyzed reactions. This highly electrophilic compound is known to be …

Apr 28, 2010 · How benzo [a]pyrene diol epoxide (BPDE), a carcinogen present in tobacco smoke as well as in environmental pollution, induces esophageal carcinogenesis has yet to be …

Sep 30, 2016 · Additional oxidation of the benzo(a)pyrene 7,8-dihydrodiol by cytochrome P450 results in the ultimate carcinogen 7,8-dihydrodiol-9,10-epoxide (BPDE). BPDE can bind to the …

Benzo(a)pyren-7,8-dihydrodiol-9,10-epoxide (BPDE) is an endocrine disrupter and ultimate carcinogenic product of benzo(a)pyrene (BaP). Numerous studies have shown that BPDE …

Previously we identified an intra-S-phase cell cycle checkpoint elicited by the DNA-damaging carcinogen benzo [a]pyrene-dihydrodiol epoxide (BPDE). Here we have investigated the roles …

The distribution of benzo[a]pyrene diol epoxide (BPDE) adducts along exons of the P53 gene in BPDE-treated HeLa cells and bronchial epithelial cells was mapped at nucleotide resolution. …

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Aug 5, 2023 · In this study, we found that BPDE exposure induced human trophoblast cell pyroptosis by up-regulating NLRP3/Caspase1/GSDMD pathway. We also identified that lnc …

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