2016年11月2日 · Carcinogenicity of benzo [a]pyrene {B [a]P, a polycyclic aromatic hydrocarbon (PAH)} involves DNA-modification by B [a]P diol epoxide (BPDE) metabolites. Adducts to serum albumin (SA) are not...

Within the present study, we applied the reactive metabolite benzo [a]pyrene diolepoxide (BPDE) in the nanomolar, non-cytotoxic concentration range in human TK6 cells and quantified the induction and repair of stable DNA adducts at the N 2 -position of guanine by HPLC with fluorescence detection.

Within the present study, we applied the reactive metabolite benzo [a]pyrene diolepoxide (BPDE) in the nanomolar, non-cytotoxic concentration range in human TK6 cells and quantified the induction and repair of stable DNA adducts at the N 2 -position of guanine by HPLC with fluorescence detection.

Benzo (a)pyrene-7,8-diol 9,10-Epoxide is a polycyclic aromatic hydrocarbon and metabolite of benzo (a)pyrene with potent cytotoxic and mutagenic properties. Benzo (a)pyrene-7,8-diol-9,10-epoxide binds directly to DNA and disrupts DNA replication. 7,8,8a,9a-Tetrahydrobenzo (10,11)chryseno (3,4-b)oxirene-7,8-diol.

Benzo (a)pyrene-7,8-diol-9,10-epoxide (BPDE) is a highly reactive DNA damage agent and can induce cell death through both p53-independent and -dependent pathways. However, little is known about the molecular mechanisms of p53-independent pathways …

Benzo(a)pyrene (B[a]P) and its ultimate active metabolite, benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE), are known to have neurotoxic effects that can damage hippocampal neurons and cause cognitive impairments.

We evaluated the levels of BPDE-DNA adducts, lnc-HZ09, and the mRNA and protein expression of members of the PLD1/RAC1/CDC42 pathway, and correlated their relative expression levels.

2023年10月1日 · Environmental benzo (a)pyrene (BaP) and its ultimate metabolite BPDE (benzo (a)pyrene-7,8-dihydrodiol-9,10-epoxide) are universal and inevitable persistent organic pollutants and endocrine disrupting chemicals. Angiogenesis in placental decidua plays a pivotal role in healthy pregnancy.

2017年12月5日 · BaP carcinogenicity is believed to occur mainly through its covalent modification of DNA, resulting in the formation of BPDE- N2 -dG, an adduct formed between deoxyguanosine and a diol epoxide metabolite of BaP, with subsequent mutation of critical growth control genes.

Knockdown of MUC1 expression significantly reduced transformation of immortalized human bronchial epithelial cells induced by benzo [a]pyrene diol epoxide (BPDE), the active form of the cigarette smoke (CS) carcinogen benzo (a)pyrene (BaP)s.