Alkaline phosphatase (ALP) is an enzyme that’s found throughout your body. ALP blood tests measure the level of ALP in your blood that comes from your liver and bones, and it’s one of the tests included in a comprehensive metabolic panel. High levels of ALP in your blood may indicate liver disease or certain bone disorders.

Bone alkaline phosphatase (BAP) is the bone-specific isoform of alkaline phosphatase. A glycoprotein that is found on the surface of osteoblasts, BAP reflects the biosynthetic activity of these bone-forming cells. BAP has been shown to be a …

Maintaining physiological phosphate balance is of crucial biological importance for bone health. Body phosphate homeostasis is determined by modulation of intestinal uptake of dietary phosphate, renal phosphate reabsorption and excretion, and the exchange of phosphate between extracellular and bone storage pools [1].

2024年10月29日 · A phosphate blood test checks the level of phosphate in your blood, which is essential for strong bones and teeth and muscle and nerve support. High or low phosphate levels point to various...

2018年5月26日 · An ALP bone isoenzyme test can detect abnormal levels of bone growth that may be associated with bone disease or another serious condition. Learn more about the purpose of this test.

2023年11月9日 · The bone-specific isoform of alkaline phosphatase is known as bone alkaline phosphatase (BAP). Doctors often order alkaline phosphatase levels to evaluate a patient's liver and bone health, but there is an abundance of encouraging data that supports its beneficial effects on gut health.

Alkaline Phosphatase, Bone Specific - The bone-specific alkaline phosphatase (BSAP) assay provides a general index of bone formation and a specific index of total osteoblast activity. BSAP and osteocalcin are the most effective markers of bone formation and are particularly useful for monitoring bone formation therapies and antiresorptive ...

Diagnosis and assessment of severity of metabolic bone disease including Paget disease, osteomalacia, and other states of high bone turnover. Monitoring efficacy of antiresorptive therapies including postmenopausal osteoporosis treatment. The assay is not intended as a screening test for osteoporosis.

In this review, we examine how dietary phosphorus is absorbed in the gut, current knowledge about P i sensing, and endocrine regulation of P i levels. Moreover, we also examine the roles of P i in different tissues, the consequences of low and high dietary phosphorus in these tissues, and the implications for healthy aging.

2020年5月3日 · In the rest of the skeleton, hypophosphatemia will result in osteomalacia due to an insufficient formation of hydroxyapatite. This review will address phosphate metabolism and its role in bone health.

2025年2月27日 · This narrative review was based on articles found by searching PubMed from its inception until July 2024 for the terms alkaline phosphatases, isozymes, isoforms, bone alkaline phosphatase, liver alkaline phosphatase, intestinal alkaline phosphatase, placental alkaline phosphatase, liver function tests, γ- glutamyltransferase, skeletal diseases ...

Phosphate is essential for skeletal mineralization, and its chronic deficiency leads to rickets and osteomalacia. Skeletal mineralization starts in matrix vesicles (MVs) derived from the plasma membrane of osteoblasts and chondrocytes.

Tricalcium phosphate (sometimes abbreviated TCP), more commonly known as Calcium phosphate, is a calcium salt of phosphoric acid with the chemical formula Ca 3 (PO 4) 2. It is also known as tribasic calcium phosphate and bone phosphate …

2023年8月28日 · Serum phosphate levels depend upon dietary intake, mobilization of phosphate from bone, and renal excretion of the phosphate. Levels of phosphate are tightly regulated since hyperphosphatemia, as seen in chronic kidney disease, is associated with significant cardiovascular morbidity, while hypophosphatemia can lead to rickets and osteomalacia.

2023年6月19日 · Bone is constantly being remodelled, with old bone broken down and new bone formed. Calcium is released from old bone and taken up by new bone. Once again, this process is regulated by parathyroid hormone (PTH). Increased PTH levels lead to increased calcium resorption from the bone into the bloodstream. Reference range: 1.6 – 6.9 pmol/L.

Some of these measures include: Bone-specific alkaline phosphatase (Bone ALP or BALP). This is an estimate of the rate of bone formation over your entire skeleton. Bone formation may sound...

2021年6月16日 · Increases osteoblast production of M-CSF (macrophage colony-stimulating factor) and RANKL, which increases number of osteoclasts.

2018年9月14日 · Inorganic phosphate (P i) is essential for signal transduction and cell metabolism, and is also an essential structural component of the extracellular matrix of the skeleton.

2025年3月10日 · Background Uncontrolled hyperphosphatemia in end stage renal disease (ESRD) increases the risk of cardiovascular disease (CVD), bone disorders, and premature mortality. Randomized controlled trials show reduced CVD risk of non-calcium-based phosphate-binders (NCBPBs) compared to CBPBs although evidence from real world data is less consistent. This study aimed to compare the effectiveness of ...

Phosphorus is an important nutrient for bone health, but intakes in the U.S. usually well-exceed requirements. This is problematic because excessive dietary phosphorus has been associated with adverse effects on bone and mineral metabolism.

2024年2月12日 · Phosphate plays a crucial role in bone health by contributing to bone formation and mineralization. It works in close interaction with calcium and vitamin D to maintain the …

2025年3月29日 · Extracellular osmolarity affects osteoblast migration; hypotonic conditions enhance it by raising intracellular pressure and activating TRPV4, which regulates cell structure via Rho/ROCK.

Serum alkaline phosphatase (ALP) plays an important role in bone metabolism. However, the association between serum ALP and bone mineral density (BMD) remains inconclusive. Therefore, this study aimed to explore the relationship …

Potassium and sodium phosphates may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: nausea, diarrhea, vomiting, stomach pain bone and joint pain Some side effects can be serious. If you experience any of these symptoms call your doctor immediately or get emergency medical treatment: (Hyper K) numbness or tingling around lips; numbness, tingling, pain ...