2014年1月1日 · Bone remodeling functions to renew the skeleton and involves sequential bone resorption and formation at the same spatial location. Both processes affect overall bone structure, while remodeling affects material properties such as microdamage, mineralization, and collagen cross-linking.

In this article, we review the nature of the physical stimulus to which bone cells mount an adaptive response, including the identity of the sensor cells, their attributes and physical environment, and putative mechanoreceptors they express.

Bone remodeling is a process where osteoclasts and osteoblasts work sequentially in the same bone remodeling unit. After the attainment of peak bone mass, bone remodeling is balanced and bone mass is stable for one or two decades until age-related bone loss begins.

2023年3月17日 · The function of bone remodeling is to adjust the architecture to meet the changing needs of the body. Bone remodeling also helps to repair microdamage in the bone matrix, which prevents the accumulation of old bone. Additionally, bone remodeling aids in maintaining plasma calcium homeostasis.

Bone modeling adapts structure to loading by changing bone size and shape and removes damage and so maintains bone strength. Remodeling is initiated by damage producing osteocyte apoptosis, which signals the location of damage via the osteocyte-canalicular system to endosteal lining cells that form …

2022年7月18日 · Bone remodeling replaces old and damaged bone with new bone through a sequence of cellular events occurring on the same surface without any change in bone shape.

Bone remodeling is carried out by a functional and anatomic structure known as the basic multicellular unit (BMU) and requires the coordinated action of four major types of bone cells: bone-lining cells, osteocytes, osteoclasts, and osteoblasts (Figure 1) (3, 4).

2021年12月1日 · Bone remodeling is a process where osteoclasts and osteoblasts work sequentially in the same bone remodeling unit. Age-related bone loss is caused by increased resorptive activity and reduced bone formation. Bone …

2016年10月6日 · Bone remodeling is a process where osteoclasts and osteoblasts work sequentially in the same bone remodeling unit. After the attainment of peak bone mass, bone remodeling is balanced and bone mass is stable for one or …

2014年11月28日 · Modeling and remodeling are achieved by the concerted action of osteoclasts and osteoblasts, either working independently (modeling) or in sequence (remodeling). Both processes are regulated by osteocytes.