bmp-4 在钙化的动脉粥样硬化斑块中差异表达，是动脉粥样硬化血管钙化与正常骨形成机制之间的连接点。 BMP-4 通过其促炎和促动脉粥样硬化作用增加斑块形成，促进氧化应激、内皮功能障碍和成骨分化。

BMP4 is a polypeptide belonging to the TGF-β superfamily of proteins. It, like other bone morphogenetic proteins, is involved in bone and cartilage development, specifically tooth and limb development and fracture repair. This particular family member plays an important role in the onset of endochondral bone formation in humans.

BMP2和BMP4已被证明能够诱导多能干细胞进入脂肪细胞，主要通过Smad途径而不是非标准途径介导。 小鼠研究通常认为，BMP4诱导干细胞沿着白色脂肪细胞谱系分化，而BMP7诱导棕色脂肪细胞分化。

2023年4月4日 · Bone morphogenetic protein 4 (BMP4) is emerging as a promising cytokine for regenerative medicine and tissue engineering. BMP4 has been shown to promote the regeneration of teeth, periodontal tissue, bone, cartilage, the thymus, hair, neurons, nucleus pulposus, and adipose tissue, as well as the formation of skeletal myotubes and vessels.

2024年12月24日 · BMP4 (Bone Morphogenetic Protein 4) is a Protein Coding gene. Diseases associated with BMP4 include Microphthalmia, Syndromic 6 and Orofacial Cleft 11. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation.

2025年2月8日 · BMP-4 is a negative regulator of VEGF-D-driven metastasis that induces vascular remodeling in lymph nodes. BMP4 loss-of-function mutations is associated with developmental eye disorders including SHORT syndrome.

骨形态发生蛋白 4 (BMP-4) 是一种多效性配体蛋白，属于 TGFβ 家族，参与血管系统循环，可以激活血管细胞上的受体。 BMP-4 结合 I 型受体 (ALK-2/-3/-6) 和 II 型受体 (BMPR2, ACVR2A)，通过其促炎和促动脉粥样硬化作用增加斑块形成，促进氧化应激、内皮功能障碍和成骨分化。 重组人 BMP-4 蛋白全长 116 个氨基酸 (S293-R408)，由 E. coli 大肠杆菌表达，不带标签。 * Please select Quantity before adding items. • Cell Rep. 2022 Dec 27;41 (13):111891. [Abstract]

2017年1月1日 · Title: BMP4 up-regulated by 630 nm LED irradiation is associated with the amelioration of rheumatoid arthritis. BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment.

2024年5月24日 · 赛尔瑞成重组人BMP-4是由大肠杆菌原核表达系统制备的重组蛋白，是在符合GMP标准要求的洁净间内制备、质检、包装 。 该产品具有高纯度，高活性，低内毒素的特点 ，已广泛应用于细胞培养相关研究和工业化生产领域，并得到了大量客户的认可。 同时，赛尔瑞成建立了完善的质量管理体系，通过 ISO9001、ISO13485质量体系双认证 ，有效保障了重组细胞因子产品的高质量和可追溯性。 来源：人源. 表达宿主：E. coli. …

The bone morphogenetic protein (BMP)-4 belongs to the TGF-β superfamily and has diverse pivotal roles during bone and cartilage formation, tissue repair, or organ and neuronal development. BMP-4 recombinant protein can ideally be used for functional assays, cell culture, and differentiation studies.