The Bischler-Napieralski Reaction allows the synthesis of 3,4-dihydroisoquinolines from the β-ethylamides of electron-rich arenes using condensation reagents such as P 2 O 5, POCl 3 or ZnCl 2. Mechanism of the Bischler-Napieralski Reaction

The Bischler-Napieralski reaction refers to an intramolecular electrophilic aromatic substitution process used to synthesize dihydroisoquinolines, which can be further oxidized to produce isoquinolines.

2023年9月9日 · Here we show a homo-Mannich reaction of cyclopropanol with imines generated via a Bischler-Napieralski reaction enables a protecting-group-free, redox economic, four-step access to the...

2014年1月1日 · The Bischler–Napieralski reaction is a significant strategy for the syntheses of isoquinolines. First, in 1893, this method was reported by August Bischler and Bernard Napieralski based on the cyclization of β -arylethylamides or β -arylethylcarbamates by intramolecular electrophilic aromatic substitution reaction, using a condensing agent ...

2021年3月31日 · An unforeseen twist in a seemingly trivial Bischler–Napieralski reaction led to the selective formation of an unexpected carbazole product. The reaction proved to be general, providing access to a range of diversely substituted carbazoles from readily available substrates.

2014年1月1日 · Augustus Bischler discovered the Bischler–Napieralski reaction while studying alkaloids at Basel Chemical Works, Switzerland with his coworker, B. Napieralski. Bernard Napieralski was affiliated with the University of Zurich.

Augustus Bischler (1865–1957) was born in South Russia. He studied in Zurich with Arthur Hantzsch. He discovered the Bischler-Napieralski reaction while studying alkaloids at Basel Chemical Works, Switzerland with his coworker, B. Napieralski.

Bischler–Napieralski reaction is an intramolecular electrophilic aromatic substitution reaction that allows for the cyclization of β-arylethylamides or β-arylethylcarbamates.

2015年9月28日 · Bischler-Napieralski (B-N) reaction is undoubtedly one of the most powerful methodologies in organic synthesis for the construction of isoquinoline moieties as important heterocyclic compounds.

ABSTRACT: An unforeseen twist in a seemingly trivial Bischler − Napieralski reaction led to the selective formation of an unexpected carbazole product. The reaction proved to be general, providing access to a range of diversely substituted carbazoles from readily available substrates.