Biglycan - Wikipedia
Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon. In humans, biglycan is encoded by the BGN gene [5] which is located on the X chromosome.
Biglycan: A Multivalent Proteoglycan Providing Structure and …
Proteolytically released from the ECM, biglycan acts as a danger signal signifying tissue stress or injury. As a ligand of innate immunity receptors and activator of the inflammasome, biglycan stimulates multifunctional proinflammatory signaling linking the …
Biglycan - an overview | ScienceDirect Topics
Biglycan is a core protein with leucine-rich repeats and chondroitin/dermatan sulfate side chains, found in the extracellular matrix of various tissues. It plays a key role in regulating collagen fibril assembly and interacts with cytokines to modulate diverse biological functions.
Biglycan: an emerging small leucine-rich proteoglycan (SLRP
2021年6月28日 · Biglycan, a class I small leucine-rich proteoglycans (SLRP), is a key component of the ECM that participates in scaffolding the collagen fibrils and mediates cell signaling.
The functional network of biglycan: A new frontier in tumor …
2023年9月11日 · Biglycan is a member of the small leucine-rich proteoglycan family. Dysregulation of biglycan leads to a broad range of clinical consequences, such as osteoclastogenesis, inflammation, cardiovascular disease, and cancer.
Biglycan: A regulator of hepatorenal inflammation and …
We propose a novel concept of hepatorenal crosstalk, that is, biglycan produced by the cirrhotic liver could constitute a circulating "messenger" for the kidneys triggering inflammation and/or autophagy ultimately affecting disease outcome.
Biglycan - an overview | ScienceDirect Topics
Biglycan, is a ubiquitously expressed class I small leucine rich proteoglycan (SLRP) of the ECM [117–119]. It consists of a 42-kDa protein core containing 10 leucine-rich repeats (LRRs) and up to two covalently bound chondroitin sulfate and/or dermatan sulfate GAG side chains.
The Extracellular Small Leucine-Rich Proteoglycan Biglycan Is a …
2021年3月16日 · In this study, we report the oncogenic role of biglycan, an extracellular proteoglycan, in gastric carcinogenesis. Biglycan was able to modulate gastric cancer aggressive features as cell survival, migration, and angiogenesis.
Biglycan Is an Extracellular MuSK Binding Protein Important for …
Biglycan is an extracellular matrix protein that is selectively enriched in postsynaptic membranes from Torpedo electric organ and is highly expressed in developing and regenerating muscle (Casar et al., 2004; Lechner et al., 2006).
The Landscape of Small Leucine-Rich Proteoglycan Impact on …
2023年7月9日 · Except for the class I SLRP decorin, to which an anti-tumorigenic role has been attributed, other SLPRs' roles have not been fully clarified. This review will focus on the functions of the class I and II SLRP members biglycan and lumican, which are correlated to various aspects of cancer development.