Bcl-2 - Wikipedia
Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death (apoptosis) [5] while other BCL2 family …
The role of BCL-2 family proteins in regulating apoptosis and …
The BCL-2 family has four main functions: inhibitory effects (BCL-2, BCL-Xl, BCL-W, BCL2-A1, and MCL-1), activation (BIM and PUMA), effector (BAX and BAK), and sensitization (NOXA). …
BCL2 Gene - GeneCards | BCL2 Protein | BCL2 Antibody
Dec 24, 2024 · BCL2 (BCL2 Apoptosis Regulator) is a Protein Coding gene. Diseases associated with BCL2 include Follicular Lymphoma and High-Grade B-Cell Lymphoma Double-Hit/Triple …
Bcl-2 family - Wikipedia
The Bcl-2 family (TC# 1.A.21) consists of a number of evolutionarily-conserved proteins that share Bcl-2 homology (BH) domains. The Bcl-2 family is most notable for their regulation of …
Therapeutic development and current uses of BCL-2 inhibition
Dec 4, 2020 · To help understand the potential and limitations of this therapy, this brief review will touch on the history of development of venetoclax, dissect its mechanism of action, and …
BCL-2 family isoforms in apoptosis and cancer - Nature
Feb 21, 2019 · BCL-2 family members play an integral role in apoptosis, but also contribute to many other cellular functions. Isoforms of almost all of the BCL-2 family members have been …
The BCL-2 protein family: opposing activities that mediate
BCL-2 family proteins have either pro- or anti-apoptotic activities that are crucial for the regulation of apoptosis, tumorigenesis and cellular responses to anti-cancer therapy.
Current Advances and Future Strategies for BCL-2 Inhibitors: …
Targeting the intrinsic apoptotic pathway regulated by B-cell lymphoma-2 (BCL-2) antiapoptotic proteins can overcome the evasion of apoptosis in cancer cells. BCL-2 inhibitors have evolved …
Mechanisms of BCL-2 family proteins in mitochondrial apoptosis
Jul 12, 2023 · BCL-2 proteins fulfil important functions in cell death as initiators, guardians and executioners of mitochondrial outer membrane permeabilization.
596 - Gene ResultBCL2 BCL2 apoptosis regulator [ (human)]
Gene ID: 596, updated on 9-Feb-2025. This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. …