The BBSome assembly is spatially controlled by BBS1 and BBS4 in …
2020年10月10日 · We show that the pre-BBSome is nucleated by BBS4 and assembled at pericentriolar satellites, followed by the translocation of the BBSome into the ciliary base …
BBSome-deficient cells activate intraciliary CDC42 to trigger actin ...
2024年11月25日 · Our findings reveal that ciliary CDC42, a RHO-family GTPase triggers in situ actin polymerization, ciliary ectocytosis, and cilia shortening in BBSome-deficient cells. …
Bardet–Biedl Syndrome ciliopathy is linked to altered …
2021年1月11日 · Bbs4 KO/KO, Bbs18 KO/KO, and non‐obese hypomorphic Bbs4 GT/GT mice showed an increased frequency of B‐cell precursors in the bone marrow, as well as low …
Primary cilia and their effects on immune cell functions and …
2022年5月1日 · Specifically, analysis of Bbs4 –/–-KO mice revealed that primary cilia dysfunction (due to the loss of Bbs4) altered B cell development in both the bone marrow and the …
Connecting autoimmune disease to Bardet–Biedl syndrome and …
2021年2月2日 · In peripheral immune tissues, spleen and lymph nodes, Bbs4‐mutant mice showed an increase in late mature B‐cell populations (IgD + IgM ‐) and a decrease in the …
BBS4 Gene - GeneCards | BBS4 Protein | BBS4 Antibody
2024年12月24日 · BBS4 (Bardet-Biedl Syndrome 4) is a Protein Coding gene. Diseases associated with BBS4 include Bardet-Biedl Syndrome 4 and Bardet-Biedl Syndrome. Among …
BBS4 is required for intraflagellar transport coordination and basal ...
2019年2月15日 · Here, we report that Bbs4-/− mice exhibit shorter and fewer olfactory sensory neuron (OSN) cilia despite retaining odorant receptor localization. Within Bbs4−/− OSN cilia, …
Loss of the ciliary gene Bbs4 results in defective thermogenesis …
2021年10月8日 · To assess metabolic effects of Bbs4-deficiency on adipose tissue function under thermal stress, we exposed mice with a whole-body ablation of the Bbs4 gene (Bbs4-KO) and …
Depletion of BBSome Subunits Alters Receptor Endocytosis and
2024年10月24日 · BBS1 knockout (KO) cells showed delayed transferrin internalisation and increased recycling of TGFBR1, promoting EMT. On the contrary, BBS4 KO cells had higher …
Reversal of ciliary mechanisms of disassembly rescues olfactory ...
2022年6月30日 · Our work using whole-body plethysmography showed that Bbs4 KO mice had a higher odor detection threshold, meaning lower odor detection sensitivity, compared with WT …
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