Dec 24, 2024 · BATF3 (Basic Leucine Zipper ATF-Like Transcription Factor 3) is a Protein Coding gene. Diseases associated with BATF3 include Hematologic Cancer and Dendritic Cell Deficiency. Among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Dendritic Cells Developmental Lineage Pathway.

Sep 28, 2020 · By programing CD8+ T cell survival and memory, BATF3 is a promising molecule to optimize adoptive T cell therapy in patients. BATF3 is a member of the AP-1 transcription factor family.

Here we show that the transcription factor Batf3 acts as a fate-decision factor with respect to Tconv versus Tregs by restraining Treg differentiation. Batf3 was preferentially expressed in effector CD4 T cells but not in Treg cells, and ectopic expression of …

Batf3−/− memory cells had an impaired ability to mount a robust recall response but remained functional. These findings reveal a novel cell intrinsic role of Batf3 in regulating CD8 T cell memory development.

Here we show that deletion of the transcription factor Batf3 ablated development of CD8α + dendritic cells, allowing us to examine their role in immunity in vivo. Dendritic cells from Batf3-/- mice were defective in cross-presentation and Batf3-/- mice lacked virus-specific CD8 + T cell responses to West Nile virus.

Feb 8, 2025 · Basic Leucine Zipper ATF-Like Transcription Factor 3 (BATF3), an AP-1 family transcription factor, is a glucocorticoid receptor coregulator whose interaction with glucocorticoid receptor is modulated by the lever arm.

Mechanistically, BATF3 regulated T cell apoptosis and longevity via the proapoptotic factor BIM. By programing CD8 + T cell survival and memory, BATF3 is a promising molecule to optimize adoptive T cell therapy in patients.

Jan 28, 2025 · Essential role for Batf3-dependent dendritic cells in regulating CD8 T-cell response during SARS-CoV-2 infection. Donor Batf3 inhibits murine lung allograft rejection and airway fibrosis. The bZIP transcription factor BATF3/ZIP-10 suppresses innate immunity by attenuating PMK-1/p38 signaling.

Jan 29, 2025 · The functions of BATF, BATF2, and BATF3 in DCs are closely related, and the compensatory mechanisms between them ensure that the immune system maintains functional stability even in the absence of one of the members. BATF3 plays a crucial role in the development of CD103 + and CD8α + dendritic cells [53, 54].

Sep 28, 2020 · Two studies reveal a role for the transcriptional regulator BATF3 as a T cell–intrinsic factor mediating effective memory responses. This finding opens future avenues of investigation and...