BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene. [ 5 ] [ 6 ] [ 7 ] The human BARD1 protein is 777 amino acids long and contains a RING finger domain (residues 46-90), four ankyrin repeats (residues 420-555), and a tandem BRCT domain (residues 568-777).

2024年12月24日 · BARD1 (BRCA1 Associated RING Domain 1) is a Protein Coding gene. Diseases associated with BARD1 include Breast Cancer and Inherited Cancer-Predisposing Syndrome. Among its related pathways are Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) and Homologous DNA Pairing and Strand Exchange.

2021年6月11日 · 研究发现，bard1通过识别泛素k63-e64位点，而非普遍存在的i44与i36位点与泛素结合，从而揭示了一种新的泛素识别模式。研究利用mst、emsa和itc等技术对上述作用界面进行了体外实验验证，揭示了bard1识别h4k20me0和h2ak15ub的结构基础。

2025年3月7日 · An inherited BARD1 mutation may affect your options for breast cancer prevention, detection and treatment. FORCE is here to guide you.

2023年7月17日 · What does a BARD1 mutation mean for my blood relatives? If you have a mutation, your biological parents, siblings, and children each have a 50% chance of having the same mutation. Your distant family members may also be at risk for having the same mutation. Males and females have an equal chance of passing down a mutation in their family.

2022年6月22日 · The full-length BRCA1-associated RING domain 1 (BARD1) gene encodes a 777-aa protein. BARD1 displays a dual role in cancer development and progression as it acts as a tumor suppressor and an oncogene. Structurally, BARD1 has homologous domains to ...

2025年2月8日 · BARD1 germline variants induce haploinsufficiency and DNA repair defects in neuroblastoma. BRCA1-BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes. Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk.

It shows that deleterious BARD1 mutations contribute to low/moderate BC risk, thus confirming the role of BARD1 in BC predisposition. An even higher effect size of the BARD1 mutations was observed for TNBC and bilateral BC, i.e., subgroups attributed to hereditary BC. Our results also indicate that the BC-predisposing role of variants of ...

bard1/brca1 相互作用被 brca1 中的致瘤性氨基酸取代破坏，这意味着这些蛋白质之间稳定复合物的形成可能是 brca1 肿瘤抑制的一个重要方面。 这种蛋白质可能是乳腺癌或卵巢癌致癌突变的靶点。

Although potentially pathogenic BARD1 variants have been reported, the role of BARD1 in cancer predisposition remains inconsistent. Here, we aim to review what is known about BARD1 as a candidate cancer predisposing gene and discuss challenges facing researchers aiming to discover additional cancer predisposing genes.