Baloxavir marboxil (BXM) is a prodrug whose active agent, baloxavir acid (BXA) is released rapidly in vivo, as the hydrolysis of baloxavir marboxil is catalyzed by arylacetamide deacetylases in cells of the blood, liver, and lumen of the small intestine.

2022年9月7日 · Baloxavir marboxil is a prescription flu antiviral drug given as a pill by mouth for treatment of flu or post exposure prevention. Baloxavir is approved for children ages 5 to 12 years who do not have chronic medical conditions for all people ages 12 years and older.

2023年8月16日 · Baloxavir marboxil is used to treat flu symptoms caused by influenza virus in people who have had symptoms for no more than 48 hours. Baloxavir marboxil will not treat the common cold. Baloxavir marboxil is also used to prevent flu symptoms in people who have been in contact with someone who has the flu .

Learn about XOFLUZA® (baloxavir marboxil), a one-dose prescription medicine flu treatment that attacks the flu virus at its source. See full safety for more information.

2018年9月5日 · Baloxavir marboxil is a selective inhibitor of influenza cap-dependent endonuclease. It has shown therapeutic activity in preclinical models of influenza A and B virus infections,...

2025年2月1日 · Baloxavir marboxil is used to treat the flu (influenza) in patients who have had flu symptoms (eg, cough, fever, runny nose, headache, joint or muscle pain) for not more than 48 hours. It is used in patients 5 years of age and older who are healthy or who are at high risk of developing flu-related complications.

2019年1月2日 · Baloxavir is approved for the treatment of influenza in patients 12 and older who have been symptomatic for no more than 48 hours. The main advantage of baloxavir is that a single oral dose is effective, whereas oseltamivir needs to be taken twice daily for five days.

Baloxavir marboxil is a prodrug that is converted by hydrolysis to baloxavir, the active form that exerts anti-influenza virus activity. Baloxavir inhibits the endonuclease activity of the polymerase acidic (PA) protein, an influenza virus-specific enzyme in the viral RNA polymerase complex required for viral gene transcription, resulting in ...

Find information for HCPs about XOFLUZA® (baloxavir marboxil), a single-dose oral antiviral treatment for influenza. See full safety for more information.

2023年9月25日 · Xofluza (baloxavir marboxil) is used for the treatment and post-exposure prophylaxis of influenza. Includes Xofluza side effects, interactions and indications.