Jul 17, 2023 · If you both have a mutation in the BRIP1 gene, which is rare, there’s a chance your child could be born with a serious condition called Fanconi Anemia (FA). FA is a genetic disorder that can cause birth defects, bone marrow failure, and a risk of cancer.

Fanconi anemia group J protein is a protein that in humans is encoded by the BRCA1-interacting protein 1 (BRIP1) gene. [5][6][7] The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1).

Mar 13, 2025 · An inherited BRIP1 mutation may affect your options for fallopian tube and ovarian cancer prevention, detection and treatment. FORCE is here to guide you.

Mar 13, 2025 · People with an inherited BRIP1 mutation have an increased risk for cancer. Read about medical options for lowering cancer risk or detecting it early. FORCE is here to guide you.

BRIP1 Mutation is a predictive biomarker for use of olaparib in patients. Of the therapies with BRIP1 Mutation as a predictive biomarker, 1 is FDA-approved and 1 has NCCN guidelines in at least one clinical setting.

Mar 13, 2025 · People with a BRIP1 mutation have a 5-15% lifetime risk of fallopian tube, ovarian or primary peritoneal cancer. These three cancers are related and are often referred to together as ovarian cancer.

Dec 24, 2024 · BRIP1 (BRCA1 Interacting DNA Helicase 1) is a Protein Coding gene. Diseases associated with BRIP1 include Fanconi Anemia, Complementation Group J and Breast Cancer. Among its related pathways are Homologous DNA Pairing and Strand Exchange and Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).

BRIP1 is a ‘cancer protection’ gene that helps to protect against ovarian cancer. Everyone has two BRIP1 genes (one from their mother, and one from their father). If one of the genes is not working, this is known as having a faulty BRIP1 gene, or having a BRIP1 mutation.

Although there are high cancer risks for patients with mutations in BRIP1, there are interventions that may be effective at reducing these risks. Guidelines from the National Comprehensive Cancer Network (NCCN) that may apply are listed below.

What is my cancer risk if I have a BRIP1 mutation? A BRIP1 mutation increases your risk for ovarian cancer. A BRIP1 mutation may also increase your risk for breast cancer, but more research is needed for us to better understand this risk.