2023年7月17日 · If you both have a mutation in the BRIP1 gene, which is rare, there’s a chance your child could be born with a serious condition called Fanconi Anemia (FA). FA is a genetic disorder that can cause birth defects, bone marrow failure, and a risk of cancer.

Fanconi anemia group J protein is a protein that in humans is encoded by the BRCA1-interacting protein 1 (BRIP1) gene. [5][6][7] The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1).

2024年2月25日 · An inherited BRIP1 mutation may affect your options for fallopian tube and ovarian cancer prevention, detection and treatment. FORCE is here to guide you.

2024年9月6日 · People with an inherited BRIP1 mutation have an increased risk for cancer. Read about medical options for lowering cancer risk or detecting it early. FORCE is here to guide you.

BRIP1 Mutation is a predictive biomarker for use of olaparib in patients. Of the therapies with BRIP1 Mutation as a predictive biomarker, 1 is FDA-approved and 1 has NCCN guidelines in at least one clinical setting.

2024年6月21日 · People with a BRIP1 mutation have a 5-15% lifetime risk of fallopian tube, ovarian or primary peritoneal cancer. These three cancers are related and are often referred to together as ovarian cancer.

2024年12月24日 · BRIP1 (BRCA1 Interacting DNA Helicase 1) is a Protein Coding gene. Diseases associated with BRIP1 include Fanconi Anemia, Complementation Group J and Breast Cancer. Among its related pathways are Homologous DNA Pairing and Strand Exchange and Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).