BRD4 - Wikipedia
Bromodomain-containing protein 4 is a protein that in humans is encoded by the BRD4 gene. [5] [6] BRD4 is a member of the BET (bromodomain and extra terminal domain) family, which also …
溴结构域蛋白4的结构和功能及其抑制剂在肿瘤研究中的应用
Brd4抑制剂通过抑制Brd4与SEs结合，加速SEs与靶向启动子的信号转导，抑制肿瘤细胞癌基因的表达，促进肿瘤细胞死亡 。Brd4抑制剂一般分为两类：单价抑制剂和二价抑制剂。单价抑制 …
BRD4 Gene - GeneCards | BRD4 Protein | BRD4 Antibody
Dec 24, 2024 · BRD4 (Bromodomain Containing 4) is a Protein Coding gene. Diseases associated with BRD4 include Cornelia De Lange Syndrome 6 and Cornelia De Lange …
BRD4蛋白研究新发现——助力治疗包括癌症在内的多种疾病 - 知乎
brd4 是一种转录和表观遗传调节因子，在胚胎发生和癌症发展过程中起着关键作用。 作为溴结构域和末端外结构域 (BET) 家族的成员，BRD4 的特征在于具有两个串联溴结构域（BD1 …
Super-enhancers and the super-enhancer reader BRD4 ... - Nature
Dec 22, 2023 · Small molecule compound BRD4 BD1 and BD2 bromodomain inhibitors block BRD4 binding to super-enhancers, suppress oncogene transcription and expression, reduce …
BRD4 and Cancer: going beyond transcriptional regulation
Nov 22, 2018 · BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and …
BRD4 and Cancer: going beyond transcriptional regulation
Nov 22, 2018 · Here we discuss the current available information on non-canonical, non-transcriptional functions of BRD4 and on their implications in cancer biology. Integrating this …
BRD4 抑制剂抗肿瘤机制研究进展 - 搜狐
May 8, 2012 · brd4 蛋白是溴结构域和超末端家族蛋白（bet）家族中最重要的功能蛋白，含两个溴结构域及一个超末端结构域。 brd4 的表达上调与肺癌、乳腺癌、急性髓系淋巴瘤、肝癌等多 …
BRD4的分子机制与生理作用 - ResearchGate
Mar 24, 2021 · BRD4 has emerged as an important factor in tumorigenesis by promoting the transcription of genes involved in cancer development. However, how BRD4 is regulated in …
【J Med Chem】广州健康院许永团队报道首个选择性BRD4 BD2抑 …
bet家族 成员 brd4 是肿瘤发生发展的重要调控因子。在 急性髓系白血病 中，异常激活的brd4定位超乙酰化启动子位点，招募 p-tefb 等中介因子，促进 myc 、 bcl-2 等原癌基因的表达，致使 …