BRCA2 and BRCA2 (/ ˌbrækəˈtuː / [5]) are human genes and their protein products, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for the protein) and the official name (originally breast cancer 2; currently BRCA2, DNA repair associated) are maintained by the HUGO Gene Nomenclature Committee.

A fact sheet about the BRCA1 and BRCA2 genes, what to do if a person tests positive for alterations in one of these genes, and consequences of genetic testing.

BRCA2 (BReast CAncer gene 2) is a gene that, when mutated, can increase a person’s lifetime risk of breast and other cancers, including ovarian, prostate, and pancreatic. Most breast cancers that arise from a BRCA2 gene mutation are estrogen receptor (ER)–positive/HER2-negative.

2024年10月2日 · Women who have a BRCA2 mutation have a 45% chance of developing breast cancer by the age of 70 (slightly lower than with a BRCA1 mutation). Men with a BRCA1 mutation also have a 1% risk of breast cancer, and a 6% risk with a BRCA2 mutation.

2023年10月21日 · The BRCA gene test looks for changes in the BRCA1 and BRCA2 genes. Other genes also can increase the risk of breast and ovarian cancer. Some genetic tests look for these other genes in addition to the BRCA genes. A genetic test that looks at many different genes is called a multigene panel test.

The BRCA2 gene provides instructions for making a protein that acts as a tumor suppressor. Tumor suppressor proteins help prevent cells from growing and dividing too rapidly or in an uncontrolled way. The BRCA2 protein is involved in repairing damaged DNA.

2025年1月8日 · BRCA2 is an established clinically actionable cancer predisposition gene 5 and has been widely used to test for hereditary cancer risk. In particular, BRCA2 loss-of-function pathogenic variants...

2024年12月24日 · BRCA2 (BRCA2 DNA Repair Associated) is a Protein Coding gene. Diseases associated with BRCA2 include Fanconi Anemia, Complementation Group D1 and Breast Cancer. Among its related pathways are Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) and Homologous DNA Pairing and Strand Exchange.

People with an inherited BRCA2 mutation have an increased risk for cancer. Read about medical options for lowering cancer risk or detecting it early. FORCE is here to guide you.

1998年9月4日 · BRCA1- and BRCA2-associated hereditary breast and ovarian cancer (HBOC) is characterized by an increased risk for female and male breast cancer, ovarian cancer (including fallopian tube and primary peritoneal cancers), and to a lesser extent other cancers such as prostate cancer, pancreatic cancer, and melanoma primarily in individuals with a ...