
BRCA2 - Wikipedia
BRCA2 and BRCA2 (/ ˌbrækəˈtuː / [5]) are human genes and their protein products, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for the protein) and the official name (originally breast cancer 2; currently BRCA2, DNA repair associated) are maintained by the HUGO Gene Nomenclature Committee.
BRCA Gene Changes: Cancer Risk and Genetic Testing
A fact sheet about the BRCA1 and BRCA2 genes, what to do if a person tests positive for alterations in one of these genes, and consequences of genetic testing.
What Is BRCA2? About the BRCA2 Mutation and More | BCRF
BRCA2 (BReast CAncer gene 2) is a gene that, when mutated, can increase a person’s lifetime risk of breast and other cancers, including ovarian, prostate, and pancreatic. Most breast cancers that arise from a BRCA2 gene mutation are estrogen receptor (ER)–positive/HER2-negative.
BRCA2 Gene Mutations and Cancer Risk in Men and Women - Verywell Health
2024年10月2日 · Women who have a BRCA2 mutation have a 45% chance of developing breast cancer by the age of 70 (slightly lower than with a BRCA1 mutation). Men with a BRCA1 mutation also have a 1% risk of breast cancer, and a 6% risk with a BRCA2 mutation.
BRCA gene test for breast and ovarian cancer risk - Mayo Clinic
2023年10月21日 · The BRCA gene test looks for changes in the BRCA1 and BRCA2 genes. Other genes also can increase the risk of breast and ovarian cancer. Some genetic tests look for these other genes in addition to the BRCA genes. A genetic test that looks at many different genes is called a multigene panel test.
BRCA2 gene - MedlinePlus
The BRCA2 gene provides instructions for making a protein that acts as a tumor suppressor. Tumor suppressor proteins help prevent cells from growing and dividing too rapidly or in an uncontrolled way. The BRCA2 protein is involved in repairing damaged DNA.
Functional evaluation and clinical classification of BRCA2 variants
2025年1月8日 · BRCA2 is an established clinically actionable cancer predisposition gene 5 and has been widely used to test for hereditary cancer risk. In particular, BRCA2 loss-of-function pathogenic variants...
BRCA2 Gene - GeneCards | BRCA2 Protein | BRCA2 Antibody
2024年12月24日 · BRCA2 (BRCA2 DNA Repair Associated) is a Protein Coding gene. Diseases associated with BRCA2 include Fanconi Anemia, Complementation Group D1 and Breast Cancer. Among its related pathways are Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) and Homologous DNA Pairing and Strand Exchange.
Cancer Screening and Prevention for People with a BRCA2 Gene …
People with an inherited BRCA2 mutation have an increased risk for cancer. Read about medical options for lowering cancer risk or detecting it early. FORCE is here to guide you.
BRCA1- and BRCA2 -Associated Hereditary Breast and Ovarian Cancer
1998年9月4日 · BRCA1- and BRCA2-associated hereditary breast and ovarian cancer (HBOC) is characterized by an increased risk for female and male breast cancer, ovarian cancer (including fallopian tube and primary peritoneal cancers), and to a lesser extent other cancers such as prostate cancer, pancreatic cancer, and melanoma primarily in individuals with a ...