2024年12月24日 · BMPR2 (Bone Morphogenetic Protein Receptor Type 2) is a Protein Coding gene. Diseases associated with BMPR2 include Pulmonary Hypertension, Primary, 1 and Pulmonary Venoocclusive Disease 1, Autosomal Dominant. Among its related pathways are Akt Signaling and Signaling by BMP.

Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase encoded by the BMPR2 gene. It binds bone morphogenetic proteins, members of the TGF beta superfamily of ligands, which are involved in paracrine signaling.

骨形态发生蛋白 ii 型受体 (bmpr2) 是跨膜丝氨酸/苏氨酸激酶骨形态发生蛋白 (bmp) 受体家族的一员。 BMP 参与软骨内骨形成和胚胎发生，通过两种 BMP 受体异质复合物的形成传递信号：I 型受体 (50-55 KD) 和 II 型受体 (70-80 KD)。

The BMPR2 gene provides instructions for making a protein called bone morphogenetic protein receptor type 2. The BMPR2 gene belongs to a family of genes originally identified for its role in regulating the growth and maturation (differentiation) of bone and cartilage.

2025年2月8日 · BMPR2 variant is the most common variant of pulmonary arterial hypertension. BMPR2 inhibits ALK2-mediated signaling by preventing ALK2 from oligomerizing with the type 2 receptors ACVR2A and ACVR2B.

BMPR2 是 BMP 途径的跨膜丝氨酸/苏氨酸激酶受体，对胚胎发生、发育和成体组织稳态至关重要。 BMP 诱导的 BMPR2 与 BMP I 型受体 (BMPR1) 的异聚复合物形成。 BMPR2 随后通过磷酸化激活 BMPR1。 之后，激活的 BMPR1 通过 SMAD1/5/8 转录因子的磷酸化将信号传播到细胞中。 之前的一项研究表明，SSc-PAH 患者的 BMPR2 蛋白减少，并且在相关小鼠模型中发现 BMPR2 的蛋白酶体降解增加。 总的来说，这些结果表明 TGF-β 可能通过其受体的降解来削弱 BMP …

2023年6月21日 · Gorrell等人采用无细胞免疫沉淀试验检测小鼠单克隆抗体3F6抑制BMPR2-ECD配体结合活性的中和能力，发现该抗体可以中和BMPR2细胞外结构域的配体结合功能。

2020年6月8日 · Background: Mutations in bone morphogenetic protein receptor type II (BMPR2) are leading to the development of hereditary pulmonary arterial hypertension (PAH). In non-hereditary forms of PAH, perturbations in the transforming growth factor-β (TGF-β)/BMP-axis are believed to cause deficient B …

2025年2月8日 · These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD.

2017年6月6日 · In humans, mutations in BMP receptor type 2 (BMPR2), a key component of BMP signaling, have been identified in the majority of patients with familial pulmonary arterial hypertension (PAH). However, only a small subset of individuals with BMPR2 mutation develops PAH, suggesting that additional modifiers of BMPR2 function play an important role ...