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  1. Nature
    https://www.nature.com › articles

    A molecular map of murine lymph node blood vascular ... - Nature

    • Blood vascular endothelial cells (BECs) control the immune response by regulating blood flow and immune cell recruitment in lymphoid tissues. However, the diversity of BEC and their origins durin… 展开

    Introduction

    The vascular endothelium lining blood vessels regulates exchange of oxygen and … 展开

    Nature
    Results

    Single-cell profiling of lymph node blood endothelial cells
    We performed single-cell RNA sequencing (scRNAseq, 10× Chromium) of sorted BEC from PLN of adul… 展开

    Nature
    Discussion

    The vascular endothelium plays a central role in lymphoid tissue development and function. Our survey of the LN blood vascular endothelium defines the diversity of EC phenotype… 展开

    Nature
    Methods

    Mice
    AplnCreER (apelin; targeted mutation 1.1)39, BALB/cJ (The Jackson Laboratory), B6.Cg-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J … 展开

    Nature
    Data availability

    The authors declare that all data supporting the findings of this study are available within the article and its Supplementary Information files or from the corresponding author upon reas… 展开

    Nature
    What is a confluent resting brain endothelial cell (Bec)?
    Confluent resting Brain Endothelial Cells (BECs) or HAs monolayers were detached from the transwell filters with Trypsin-EDTA (Gibco). Single cell suspension was subsequently incubated in resting medium at 37°C for 1 hour prior to the staining. All antibodies were directly labeled and purchased from BD Pharmingen.
    journals.plos.org
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    目录
    Introduction
    Results
    Discussion
    Methods
    Data availability
    What is a confluent resting brain endothelial cell (Bec)?
     
  1. Brain endothelial cells (BECs) are key constituents of the blood-brain barrier (BBB), protecting the brain from pathogens and restricting access of circulatory factors.
    了解详细信息：
    Brain endothelial cells (BECs) are key constituents of the blood-brain barrier (BBB), protecting the brain from pathogens and restricting access of circulatory factors.

    Brain Endothelial Cells Are Exquisite Sens…

    www.sciencedirect.com/science/article/pii/S221112…
    Brain microvascular endothelial cells (BEC) constitute the blood-brain barrier (BBB) which forms a dynamic interface between the blood and the central nervous system (CNS).

    Transcriptional Profiling of Human Brain …

    journals.plos.org/plosone/article?id=10.1371/journa…
  2. ScienceDirect
    https://www.sciencedirect.com › science › article › pii

    Brain Endothelial Cells Are Exquisite Sensors of Age-Related ...

  3. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    Blood–brain barrier endothelial cells in neurodegenerative …

  4. plos.org
    https://journals.plos.org › plosone › article

    Transcriptional Profiling of Human Brain Endothelial …

    2012年5月31日 · Brain microvascular endothelial cells (BEC) constitute the blood-brain barrier (BBB) which forms a dynamic interface between the blood and the central nervous system (CNS). This highly specialized interface restricts …

  5. AHA/ASA Journals
    https://www.ahajournals.org › doi

    Identification of Clinically Relevant Brain Endothelial …

    2023年10月10日 · Brain endothelial cells (BECs) are the primary cell type of the blood-brain barrier (BBB), where their tight junctions lining the neurovasculature enable them to function as unique mediators of brain homeostasis, including …

  6. BEC cells的图片

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  7. Nature
    https://www.nature.com › articles

    Proteomics of mouse brain endothelium uncovers dysregulation of ...

  8. American Society of Hematology
    https://ashpublications.org › blood › article › ...

    Blood and lymphatic endothelial cell-specific …

    2007年6月1日 · Here, we define the human BEC- and LEC-specific in vivo transcriptomes by comparative genomewide expression profiling of freshly isolated cutaneous EC subsets and of non-EC skin cells (fibroblasts, mast …

  9. MDPI
    https://www.mdpi.com

    Brain Endothelial Cells Play a Central Role in the …

    2023年6月11日 · Translocated NFkB promotes the synthesis and secretion of BEC proinflammatory cytokines and chemokines. Specifically, the chemokine CCL5 (RANTES) is capable of attracting microglia cells to BECs. BEC …

  10. ScienceDirect
    https://www.sciencedirect.com › science › article › pii

    Blood and lymphatic endothelial cell-specific ... - ScienceDirect

  11. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    Differential Gene Expression of Primary Cultured Lymphatic and …