A structural platform for B cell receptor signaling
2022年9月15日 · Upon antigen binding, BCRs cluster in the plasma membrane, resulting in phosphorylation of ITAMs. The resulting signaling cascade drives B cell–T cell collaboration …
B Cell Receptor Complex: Key to Immune Response and B Cell …
2025年1月12日 · The B cell receptor complex is a sophisticated molecular assembly integral to the immune system’s ability to recognize and respond to antigens. At its core, the BCR is …
The regulators of BCR signaling during B cell activation
BCR is the specific surface marker of B cells, consisting of an extracellular region, transmembrane (TM) region, and intracellular region. According to the latest research, most of …
Dynamics and activation of membrane-bound B cell receptor …
2025年2月13日 · Recently, the first cryo-EM structures of the human B-cell antigen receptor of the IgM and IgG isotypes have been published that validates the asymmetric organization of the …
Structural principles of B cell antigen receptor assembly
2022年10月13日 · Our studies provide a structural platform for understanding B cell signalling and designing rational therapies against BCR-mediated diseases. B cells can recognize …
B-Cell Receptor - an overview | ScienceDirect Topics
The B cell receptor (BCR) interacts with foreign antigens to mediate B cell activation and secretion of antibodies. B cell activation begins with initiation of signaling pathways, such as NFAT, NF …
BCR Composition and Structure - SpringerLink
2025年2月26日 · The complete BCR complex consists of six chains: two mIg heavy chains and two mIg light chains covalently linked by disulfide bonds, forming a tetrameric chain structure …
B Cell Receptor Structure: Key Components and Functions
2025年3月11日 · The B cell receptor (BCR) is a molecular complex essential for the immune system’s antigen identification and binding. It consists of membrane-bound immunoglobulin …
B Cell Receptor Signaling: Key Steps, Functions, and Impact
2025年3月14日 · The B cell receptor (BCR) is a multiprotein complex that enables B cells to detect antigens with high specificity. At its core, the BCR consists of a membrane-bound …
Role of the BCR complex in B cell development, activation, and
Here we describe work demonstrating the importance of signaling via the pre-B cell receptor complex (pre-BCR) to the pre-B cell transition, the central checkpoint in B-cell development.
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