The Bcl-2 family proteins consists of members that either promote or inhibit apoptosis, and control apoptosis by governing mitochondrial outer membrane permeabilization (MOMP), which is a key step in the intrinsic pathway of apoptosis.

Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death (apoptosis) [5] while other BCL2 family members can either inhibit or induce it. [6][7] It was the …

Members of the B-cell lymphoma 2 (BCL-2) protein family have pro- or anti-apoptotic activities and have been studied intensively over the past decade for their importance in regulating apoptosis, tumorigenesis, and cellular responses to anticancer therapy.

The Bcl-2 family is defined by homology shared within four conserved regions in Bcl-2, termed BCL-2 homology (BH) domains, and is grouped into three subfamilies depending on their apoptotic properties, i.e. the pro-apoptotic Bax- and BH3 …

The Bcl-2 family of proteins is formed by pro- and antiapoptotic members. Together they regulate the permeabilization of the mitochondrial outer membrane, a key step in apoptosis.

2008年7月1日 · Here, we discuss the mechanisms by which Bcl-2 family members, well-characterized regulators of apoptosis, also regulate autophagy. Bcl-2 is the prototype of a family of proteins containing at least one Bcl-2 homology (BH) region.

2011年7月7日 · Here, we will focus on the mechanisms by which Bcl-2 family members elicit MOMP during apoptosis. We will also review the link that connects some Bcl-2 family proteins with fission and fusion of the organelle in apoptosis and in healthy cells.

Key anti-apoptotic BCL-2 family members and their roles in development. This includes the common names, protein names, mouse genomic identity, and references to literature elucidating their roles in early embryogenesis, nervous system development, and hematopoiesis.

2019年2月21日 · BCL-2 family members play an integral role in apoptosis, but also contribute to many other cellular functions. Isoforms of almost all of the BCL-2 family members have been identified and some...

2017年11月17日 · We address the critical importance of both the concentration and affinities of BCL-2 family proteins and show how differences in either can greatly change the outcome.