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2018年12月5日 · The blood-brain barrier (BBB) is a highly complex and dynamic structure, mainly composed of brain microvascular endothelial cells, pericytes, astrocytes and the basement membrane (BM). The vast majority of BBB research focuses on its cellular constituents. Its non-cellular component, the BM, on the …

2025年1月17日 · Gatekeeper or accomplice? That is the paradoxical role of the blood-brain barrier (BBB) in developing brain metastasis (BM). BM occurs when cancerous cells from primary cancer elsewhere in the body gain the ability to metastasize and invade the brain parenchyma despite the formidable defense of the …

2020年4月1日 · Both pericytes and astrocytes are separated from the BMECs by a vascular basement membrane (BM). The BM provides mechanical support to the BMECs and retains most of the biochemical cues secreted by the surrounding cells. The diffusion gradient of these biochemical cues oriented towards the BBB strongly influences BBB integrity [16,17].

血脑屏障（bbb）的 基底膜 （bm）是 脑微血管内皮细胞 （bmecs）下方的一种薄薄的细胞外基质（ecm）片，在调节血脑屏障独特的生理屏障功能中起着至关重要的作用，也是脑部药物传递的主要障碍。 由于在体外难以模拟bm独特的生化特征，目前的体外血脑屏障模型的生理相关性较差。

商业改进局（英语： Better Business Bureau ，简称BBB）是一个成立于1912年的非营利组织，其目标是促进建立公平有效的市场，以便买家和卖家能够建立互信。 它由美国、加拿大和墨西哥的超过106家独立本地组织联合组成，由位于维吉尼亚州阿灵顿的国际商业改进局协会（International Association of Better ...

2025年1月17日 · Gatekeeper or accomplice? That is the paradoxical role of the blood–brain barrier (BBB) in developing brain metastasis (BM). BM occurs when cancerous cells from primary cancer elsewhere in the body gain the ability to metastasize and invade the brain parenchyma despite the formidable defense of the BBB. These metastatic cells manipulate the BBB’s components, changing them from gatekeepers ...

2018年11月19日 · 血脑屏障（bbb）对于功能性神经血管单位必不可少。大多数研究集中在形成bbb的细胞上，但是很少研究衰老时脑毛细血管的基底膜（bm）。我们使用透射电子显微镜和电子断层扫描来研究衰老的c57bl / 6j小鼠中血脑屏障的bm。24个月大小鼠的bbb bm厚度是6个月大小鼠的bm厚度的两倍（107 nm对56 nm）。

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