The BAP1 gene provides instructions for making a protein called ubiquitin carboxyl-terminal hydrolase BAP1 (shortened to BAP1). This protein functions as a deubiquitinase, which means it removes a molecule called ubiquitin from certain proteins.

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) is a deubiquitinating enzyme that in humans is encoded by the BAP1 gene. [5] [6] BAP1 encodes an 80.4 kDa nuclear-localizing protein with a ubiquitin carboxy-terminal hydrolase (UCH) domain that gives BAP1 its deubiquitinase activity. [5]

2024年12月24日 · BAP1 (BRCA1 Associated Deubiquitinase 1) is a Protein Coding gene. Diseases associated with BAP1 include Kury-Isidor Syndrome and Tumor Predisposition Syndrome 1. Among its related pathways are Metabolism of proteins and HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA).

2018年2月1日 · One novel candidate identified on reverse-phase protein array analysis (RPPA) screening was the BRCA1-associated protein-1 (BAP1), a nuclear deubiquitinating enzyme consisting of 729 amino acids. BAP1 regulates a number of cellular processes, including cell cycle, cell differentiation, transcription, and DNA damage response (DDR).

BRCA1-associated protein 1 (BAP1) is emerging as an intensively studied cancer-associated gene. Germline mutations in BAP1 lead to a cancer syndrome, and somatic loss is found in several cancer types. BAP1 encodes a deubiquitinase enzyme, which plays key roles in cell cycle regulation, cell death, and differentiation.

2021年1月22日 · The BAP1 complex is an evolutionary conserved, multiprotein complex that functions as a general transcriptional activator via deubiquitination of H2AK119Ub and other epigenetic/transcription...

BRCA1关联蛋白1 （BAP1）是一种 泛素蛋白羧基末端水解酶，已被确立为肿瘤抑制因子，利用其去泛素化活性来调节许多生物过程，包括DNA损伤修复，细胞周期控制，染色质修饰，程序性细胞死亡，和免疫反应。 BAP1基因的突变通常会导致多种侵袭性癌症。 主要为 葡萄膜黑色素瘤， 恶性间皮瘤， 肾细胞癌 和 皮肤黑色素瘤。 重要的是，BAP1基因的种系突变已被确定为一种新型的肿瘤易感综合征的遗传驱动力，其导致遗传性、早发性癌症的风险增加。 当前治疗BAP1突变 …

2022年9月30日 · We report the identification of the methyl-CpG-binding domain proteins 5 and 6 (MBD5 and MBD6) that bind to the C-terminal PHD fingers of the large scaffold subunits ASXL1-3 and stabilize the BAP1 complex at the chromatin.

2020年11月1日 · BRCA1-Associated Protein 1 (BAP1) is a ubiquitin carboxy-terminal hydrolase that has been established as a tumor suppressor, utilizing its deubiquitinating activity to regulate a number of processes including DNA damage repair, cell cycle control, chromatin modification, programmed cell death, and the immune response.

BRCA1-Associated Protein 1 (BAP1) is a ubiquitin carboxy-terminal hydrolase that has been established as a tumor suppressor, utilizing its deubiquitinating activity to regulate a number of processes including DNA damage repair, cell cycle control, chromatin modification, programmed cell death, and the immune response.