HLA Class I Knockout Converts Allogeneic Primary NK Cells Into …
2021年1月29日 · After knocking-out surface expression of HLA class I molecules by targeting the B2M gene via CRISPR/Cas9, we also co-expressed a single-chain HLA-E molecule, thereby …
B2M overexpression correlates with malignancy and immune
2021年3月3日 · B2M positively correlated with multiple infiltrating immune cell types, such as NK cells, CD4+ T effector memory cells (TEM), and CD8+ TEM, which play a critical role in anti …
Beta2-microglobulin (B2M) in cancer immunotherapies: Biological ...
2021年10月1日 · Radiation, NK cell-based therapies and MHC-independent immunotherapies such as adoptive CAR-T cells and MHC class II-restricted cancer vaccines can achieve better …
Donor natural killer cells trigger production of β-2-microglobulin …
2022年12月1日 · Here, in murine models, we show that infusion of donor alloreactive NK cells triggers recipient dendritic cells (DCs) to synthesize β-2-microglobulin (B2M) that elicits the …
Engineering immune-evasive allogeneic cellular immunotherapies
2024年4月24日 · Here, iPS cell-derived T cells with triple knockout of B2M, CIITA and CD155, combined with HLA-E overexpression, were shown to resist to killing by allogeneic T and NK …
Frontiers | HLA Class I Knockout Converts Allogeneic Primary NK …
2021年1月28日 · After knocking-out surface expression of HLA class I molecules by targeting the B2M gene via CRISPR/Cas9, we also co-expressed a single-chain HLA-E molecule, thereby …
B2M gene expression shapes the immune landscape of lung adenocarcinoma ...
We showed that B2M expression has a significant impact on the immune landscape in LUAD; B2M hi tumours feature enhanced infiltration of immune cells, including CD8 + T and NK cells, …
Nature子刊：避免异体CAR-T免疫排斥问题，基因编辑iPSC细胞具 …
2021年6月1日 · 这项研究证明了通过敲除iPSC中HLA-I（B2M）、HLA-II基因（CIITA）和NK细胞激活性配体（PVR），并敲入NK细胞抑制性配体（HLA-E）所获得的同种异体多能干细胞， …
A vaccine targeting resistant tumours by dual T cell plus NK cell ...
2022年5月25日 · Here we report a cancer vaccine that induces a coordinated attack by diverse T cell and natural killer (NK) cell populations. The vaccine targets the MICA and MICB (MICA/B) …
癌症免疫疗法中的β2-微球蛋白（B2M）：生物学功能、耐药性和 …
β2-微球蛋白 (b2m) 是主要组织相容性复合物 (mhc) i 类的重要亚基，在肿瘤发生和免疫控制中发挥重要的生物学功能。 越来越多的证据表明，B2M 基因和 B2M 蛋白的改变通过抑制抗原呈递 …