002087 - B2m KO Strain Details - The Jackson Laboratory
Immune responses involving CD8<sup>+</sup> T-cells are severely deficient, providing a model to assess the role of CD8<sup>+</sup> cells and class I MHC in various experimental systems.
HLA Class I Knockout Converts Allogeneic Primary NK Cells Into …
Jan 29, 2021 · After knocking-out surface expression of HLA class I molecules by targeting the B2M gene via CRISPR/Cas9, we also co-expressed a single-chain HLA-E molecule, thereby …
Generation of a B2M homozygous knockout human somatic cell …
Mar 1, 2022 · Here, we generated a B2M homozygous knockout somatic cell nuclear transfer-induced embryonic stem cell (SCNT-ESC) line using CRISPR/Cas9-mediated gene targeting. …
Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates …
Apr 4, 2019 · As an alternative to HLA homozygous iPSCs, researchers have been using genome-editing technologies to knock out the β2-microglobulin (B2M) gene.
Efficient gene knockout in primary human and murine myeloid cells …
Highly efficient gene editing in primary myeloid cells is made possible by optimized non-viral delivery of CRISPR-Cas9. This enables single and multiplexed gene knockout in monocytes, …
NCG-B2m-KO Mouse | Charles River
NCG-B2m-KO is a triple-immunodeficient NCG mouse with a B2m gene knockout. B2M (also known as Ly-m11, beta2m, beta2-m, β2-microglobulin) is a component of the MHC complex …
B2m-KO - 南模生物
敲除B2m基因exon2-3,建立B2m基因敲除小鼠模型。 纯合敲除小鼠在细胞表面上几乎没有任何MHC I类蛋白表达。 CD8+细胞毒性T细胞很少，并且在某些情况下CD4+细胞毒性T细胞代偿性 …
NKG B2m KO | Service - Cyagen
NKG B2m KO mice are constructed by knocking out the B2m gene on the background of NKG mice. Compared with NKG mice, NKG B2m KO mice have a significantly longer survival …
MHCII/B2m-KO(NMG) - 南模生物
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重 …
Identification of a Novel Function of B2M Involving T-Cell …
Nov 5, 2024 · SELPLG was found to be upregulated in B2M KO A20 cells compared to B2M WT cells. Tumor growth reduction was observed in both A20 B2M wt and KO cell transplanted …