Immune responses involving CD8⁺ T-cells are severely deficient, providing a model to assess the role of CD8⁺ cells and class I MHC in various experimental systems.

2021年1月29日 · After knocking-out surface expression of HLA class I molecules by targeting the B2M gene via CRISPR/Cas9, we also co-expressed a single-chain HLA-E molecule, thereby …

2022年3月1日 · Here, we generated a B2M homozygous knockout somatic cell nuclear transfer-induced embryonic stem cell (SCNT-ESC) line using CRISPR/Cas9-mediated gene targeting. …

2024年11月5日 · SELPLG was found to be upregulated in B2M KO A20 cells compared to B2M WT cells. Tumor growth reduction was observed in both A20 B2M wt and KO cell transplanted …

Highly efficient gene editing in primary myeloid cells is made possible by optimized non-viral delivery of CRISPR-Cas9. This enables single and multiplexed gene knockout in monocytes, …

2021年1月28日 · After knocking-out surface expression of HLA class I molecules by targeting the B2M gene via CRISPR/Cas9, we also co-expressed a single-chain HLA-E molecule, thereby …

NCG-B2m-KO is a triple-immunodeficient NCG mouse with a B2m gene knockout. B2M (also known as Ly-m11, beta2m, beta2-m, β2-microglobulin) is a component of the MHC complex …

B2M KO cell line, which does not express HLA-I molecules on cell surface, has pluripotency and differentiation ability to three germ layers. This cell line provides a useful cell source for …

NKG B2m KO mice are constructed by knocking out the B2m gene on the background of NKG mice. Compared with NKG mice, NKG B2m KO mice have a significantly longer survival …

B-NDG B2m KO mice plus are well suited for human immune system engraftment. Human PBMC (5E6) were intravenous implanted into homozygote B-NDG B2m KO mice plus and B-NDG …