A beta-2 microglobulin (B2M) tumor marker test usually measures the amount of B2M in your blood. It can help find out how serious your cancer may be. Learn more.

β 2 microglobulin (B2M) is a component of MHC class I molecules. MHC class I molecules have α 1, α 2, and α 3 proteins which are present on all nucleated cells (excluding red blood cells). [5] [6] In humans, the β 2 microglobulin protein [7] is encoded by the B2M gene. [6] [8]

Beta-2 microglobulin is a blood, urine or cerebrospinal fluid test to help stage a disease (an elevated B2M may indicate metastasis) and monitor treatment response.

Dec 24, 2024 · Complete information for B2M gene (Protein Coding), Beta-2-Microglobulin, including: function, proteins, disorders, pathways, orthologs, and expression.

Feb 11, 2021 · Beta-2 microglobulin (B2M), used as a tumor marker, is high in multiple myeloma or other types of cancer (lymphoma, leukemia, etc.).

A serum beta-2-microglobulin (beta-2-M) value of less than 4 mcg/mL is a good prognostic factor in patients with multiple myeloma. In a study of pretreatment serum beta-2-M levels in 100 patients with myeloma, it was reported that the median survival of patients with values greater than 4 mcg/mL was 12 months, whereas median survival for patients with values less than 4 …

Mar 8, 2025 · Title: Plasma Proteomics Identifies B2M as a Regulator of Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction.

Beta-2-microglobulin (B2M) is a protein that is found on the surface of almost all cells in the body and is shed by cells into the blood, particularly by B lymphocytes and tumour cells. It is present in most body fluids and its level rises with conditions that increase cell production and/or destruction, or that activate the immune system.

Oct 1, 2021 · B2M, an important subunit of the MHC class I molecule, has diverse functions in physiological and pathological conditions both in tumor cells and non-tumor cells, especially playing an important role in immune surveillance. B2M mutations have been identified in considerable cancer patients.

Jan 1, 2018 · Beta-2 microglobulin (B2m) is the 11.8 kDa light-chain moiety of major histocompatibility complex class I (MHC I) present on the surface of nearly all nucleated cells . MHC I functions immunologically in antigen presentation to cytotoxic T cells

Nov 3, 2024 · Clinical resource with information about B2M, Familial visceral amyloidosis, Ostertag type, Hypoproteinemia, hypercatabolic, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

¿Qué es B2M? Contáctanos Términos y Condiciones Política de Privacidad y Protección de Datos Personales Clientes proveedores: - Mesa de Ayuda: Lunes a Viernes de 8:00 a 18:00 hrs, Sábados de 9 a 12 hrs (GMT-5) - +51 518 3360 - [email protected] .

Apr 25, 2024 · The Beta-2 Microglobulin (B2M) blood test is an important diagnostic tool used to measure the level of beta-2 microglobulin in the blood. This protein, part of the major histocompatibility complex (MHC) class I molecules, plays a role in the immune system and can be elevated in certain diseases. Purpose of the B2M Blood Test

Feb 9, 2025 · B2M gene expression shapes the immune landscape of lung adenocarcinoma and determines the response to immunotherapy. Frequent mutated B2M, EZH2, IRF8, and TNFRSF14 in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype.

Serum β-2 microglobulin (Β2M), a major histocompatibility complex class I molecule that is a biomarker of kidney filtration and increased cell turnover, is elevated at the time of diagnosis in hematological and some solid cancers. However, serum Β2M was not examined prospectively as a marker for cancer risk.

Nov 11, 2015 · Beta-2-microglobulin is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells (Gussow et al., 1987). Cunningham et al. (1973) reported the complete amino acid sequence of the beta-2-microglobulin protein.

Beta-2-Microglobulin, Urine - Beta-2-Microglobulin (B2M) is a low molecular weight protein that forms the light chain component of the histocompatibility antigen. It is synthesized by all nucleated cell types.

Jan 11, 2019 · Taken together, our data reveal a novel function for B2M as a negative feedback regulator of inflammation via MDSC induction that could also contribute to immune evasion in smoldering...

Oct 1, 2021 · B2M, an important subunit of the MHC class I molecule, has diverse functions in physiological and pathological conditions both in tumor cells and non-tumor cells, especially playing an important role in immune surveillance. B2M mutations have been identified in considerable cancer patients.

Mar 1, 2021 · Beta-2-microglobulin (B2M) has been suggested as an emerging biomarker for cardiovascular diseases (CVD), including coronary heart disease (CHD) and stroke, and mortality. Three databases were searched from inception to January 2, 2020, supplemented by scanning reference lists of identified studies.