Azetidine | C3H7N | CID 10422 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Azetidine is a thermally stable, colorless liquid with a strong ammonia odor that can be synthesized through the cyclization of γ-substituted amines or by reacting 1,3-dihalopropane with p-toluenesulfonamide under basic conditions.

2021年3月25日 · Azetidines represent one of the most important four-membered heterocycles used in organic synthesis and medicinal chemistry. The reactivity of azetidines is driven by a considerable ring strain, while at the same the ring is significantly more stable than that of related aziridines, which translates into both facile handling and unique reactivity that can be triggered under appropriate ...

2020年1月1日 · Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products. Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Owing to its satisfactory stability, molecular rigidity, and chemical and biological properties, azetidine has emerged as a valuable scaffold and it has drawn the attention of medicinal researchers.

Palladium-catalyzed intramolecular amination of unactivated C-H bonds at the γ and δ positions of picolinamide (PA) protected amine substrates enables the synthesis of azetidine, pyrrolidine, and indoline compounds.

2021年6月29日 · Azetidine is an almost unexplored nitrogen-containing saturated heterocycle with many pharmacological activities. This review article highlights the traditional method of synthesis of this valuable s...

2025年1月27日 · Azetidine is a flammable, hygroscopic liquid smelling of ammonia, which absorbs CO2 from air and should be kept under Argon. Purify it by drying it over solid KOH and distilling it through a short Vigreux column (p 11) at atmospheric pressure (under Argon) and keeping the pot temperature below 210o.

2020年9月23日 · Importantly, the accessible azetidine products can be readily converted into free, unprotected azetidines, which represents a new approach to access these highly desirable synthetic targets.

2022年4月12日 · Azetidines are an important class of aza-heterocyclic compounds with remarkable biological activities [1]. Among those, azetidine-2-ones (β-lactams) have attracted the greatest interest owing to their key role in antibacterial activity [2]. Presently, ca. 60 approved and over 30 experimental drugs bear the moiety of azetidine-2-one [3].