2024年12月24日 · The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this …

What Is the AXIN2 Gene? AXIN2 is a gene that you inherit from your parents. If you develop changes, or mutations, in this gene, it won’t function the way it should. If You Carry an AXIN2 …

2025年1月4日 · The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this …

The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have …

In vertebrates, there are two forms of Axin, Axin1 and Axin2, which are similar at the protein level and genetically redundant. We show here that differential regulation of the two genes on the …

Axin2 is a target of Wnt transcriptional activation that feeds back negatively on the pathway, promoting β-catenin degradation. We show Axin2 function is essential for normal kinetics of …

Lu et al. reported that AXIN2 was identified to be a functional downstream target of miR-374a, and decreased expression of Axin2 could promote OS cell proliferation. Previous studies have also …

2025年2月8日 · The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this …

Uniquely, AXIN2, but not AXIN1, is a transcriptional target of β-catenin-dependent Wnt signaling [34–36], and AXIN2 expression is elevated in cancers with activating Wnt pathway mutations.

The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have …