The Role of Aurora B Kinase in Normal and Cancer Cells
2023年12月27日 · In this review, we discuss the functions of Aurora B, the relationship between increased Aurora B activity and carcinogenesis, and the prospects for the use of Aurora B kinase inhibitors in antitumor therapy.
Making the Auroras glow: regulation of Aurora A and B kinase …
Two kinases are involved directly in the activation of Aurora B. C. elegans Tousled-like kinase (TLK-1) is a substrate activator that increases Aurora B activity in an INCENP-dependent manner . The checkpoint kinase Chk1 phosphorylates Aurora B and increases its activity at the centromere [ 81 ].
Aurora kinases: novel therapy targets in cancers - PMC
Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A (AURKA), Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via regulating mitosis especially the process of chromosomal segregation.
Aurora Kinase B Expression, Its Regulation and Therapeutic …
Aurora kinase B (AURKB) plays a pivotal role in the regulation of mitosis and is gaining prominence as a therapeutic target in cancers; however, the role of AURKB in retinoblastoma (RB) has not been studied.
The functional diversity of Aurora kinases: a comprehensive review
2018年9月19日 · In this review, we aim to understand the functional interplay of Aurora kinases in various types of human cells, including tumor cells. The understanding of the functional diversity of Aurora kinases could help to evaluate their relevance as potential therapeutic targets in cancer.
Aurora B kinase: a potential drug target for cancer therapy
Results: ABK plays an instrumental in mitotic entry, chromosome condensation, spindle assembly, cytokinesis, and abscission. Small-molecule inhibitors of ABK are designed and synthesized to control cancer progression.
Aurora B Kinase - an overview | ScienceDirect Topics
Aurora B kinases are ‘chromosomal passenger’ proteins, which are found in cells in a complex with the inner centromere protein (INCENP) and survivin. The overexpression of an Aurora B kinase-dead mutant (K-R) causes multiple defects in the mitotic machinery, including the loss of kinetochore attachment to microtubules [48–50].
Aurora B - PMC - National Center for Biotechnology Information
2013年4月1日 · Aurora B (Aurkb) is one of the major protein kinases that ensures the proper execution and fidelity of mitosis. 1 A member of the chromosomal passenger complex, Aurkb has been implicated in various mitotic functions, including chromosome-microtubule interactions, sister chromatid cohesion, the spindle-assembly checkpoint and cytokinesis. 2 As ...
Aurora B Kinase - an overview | ScienceDirect Topics
While Aurora A kinase is implicated in regulating mitotic entry, centrosome maturation, and spindle assembly, Aurora B is required for correct chromosome segregation and cytokinesis. In this review, we summarize the roles of Aurora A and B …
The deubiquitinating enzyme complex BRISC regulates Aurora B …
2022年12月6日 · Mutation of Aurora B at its primary K63 ubiquitin site inhibits its activation, reduces its kinase activity, and disrupts the association of Aurora B with other components of CPC, leading to...
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