Aurora kinase B - Wikipedia
Expression of Aurora B reaches a maximum at the G2-M transition, whereas Aurora B protein is most active during mitosis. [6] Aurora B is a chromosomal passenger protein. Specifically, Aurora B localizes to the chromosomes in prophase, the centromere in prometaphase and metaphase, and the central mitotic spindle in anaphase. [8]
Aurora B: a new prognostic marker and therapeutic target in cancer
Aurora B is a chromosomal passenger protein involved in chromosome segregation, spindle-checkpoint, and cytokinesis. Alteration of each of these steps could induce aneuploidy, one of main features, and driving force of cancer progression.
Aurora B kinase: a potential drug target for cancer therapy
Results: ABK plays an instrumental in mitotic entry, chromosome condensation, spindle assembly, cytokinesis, and abscission. Small-molecule inhibitors of ABK are designed and synthesized to control cancer progression.
The Role of Aurora B Kinase in Normal and Cancer Cells
2023年12月27日 · In this review, we discuss the functions of Aurora B, the relationship between increased Aurora B activity and carcinogenesis, and the prospects for the use of Aurora B kinase inhibitors in antitumor therapy.
Aurora-B kinase pathway controls the lateral to end-on ... - Nature
2017年7月28日 · By tracking kinetochore movements and using kinetochore markers specific to attachment status, we reveal a spatially defined role for Aurora-B kinase in retarding the end …
Frontiers | The Aurora B Kinase in Chromosome Bi-Orientation …
2015年10月15日 · In this review, we discuss the role of Aurora B in the regulation of chromosome segregation, focusing in particular on the roles of Aurora B during prometaphase, the phase of mitosis during which chromosomes attempt to create stable interactions with spindle microtubules.
Aurora Kinase B Expression, Its Regulation and Therapeutic …
Aurora kinase B (AURKB) plays a pivotal role in the regulation of mitosis and is gaining prominence as a therapeutic target in cancers; however, the role of AURKB in retinoblastoma (RB) has not been studied.
Aurora B Inhibitors as Cancer Therapeutics - MDPI
2023年4月11日 · Aurora B in the CPC ensures faithful chromosome segregation and promotes the correct biorientation of chromosomes on the mitotic spindle. Aurora B overexpression has been observed in several human cancers and has been associated with …
Aurora B Is Regulated by the Mitogen-activated Protein Kinase ...
2012年8月8日 · Aurora B is a potential therapeutic target in vemurafenib-resistant melanoma cells. A and B, XTT proliferation assay was performed on the vemurafenib-sensitive (S) and -resistant (R) melanoma cells (#1, left panel and WM9, right panel) treated with increasing concentrations of vemurafenib or AZD1152 for 48 h.
The deubiquitinating enzyme complex BRISC regulates Aurora B …
2022年12月6日 · These findings define the role of K63-linked ubiquitination in regulating Aurora B activation and provide a potential site for Aurora B-targeting drug design.
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