Here, we identify the mitochondrial α‐F 1 ‐ATP synthase (ATP5A) as a target for J147. By targeting ATP synthase, J147 causes an increase in intracellular calcium leading to sustained …

Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is …

F-type ATPases consist of two structural domains, F 1 - containing the extramembraneous catalytic core and F 0 - containing the membrane proton channel, linked together by a central …

Dec 24, 2024 · ATP5F1A (ATP Synthase F1 Subunit Alpha) is a Protein Coding gene. Diseases associated with ATP5F1A include Combined Oxidative Phosphorylation Deficiency 22 and …

Mitochondrial membrane ATP synthase (F 1 F 0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron …

Mar 28, 2023 · In the F 1 region, three α subunits (ATP5A) and three β subunits (ATP5B) form a hexamer with six ADP/ATP binding sites, among which only the β subunits are capable of …

Complex V uses the energy created by the proton electrochemical gradient to phosphorylate ADP to ATP. This review covers the architecture, function and assembly of complex V. The role of …

Nov 28, 2023 · Selected proteins (HK1, ATP5A, SRI and ARHGDIB) were subjected to validation by immunoblotting. Thereby, significant differential expression could be confirmed for HK1 and …

Nov 11, 2015 · Here, we found that ATP synthase subunit α (ATP5A) was O-GlcNAcylated at Thr432 and ATP5A O-GlcNAcylation was decreased in the brains of AD patients and …