2024年12月24日 · ATOX1 (Antioxidant 1 Copper Chaperone) is a Protein Coding gene. Diseases associated with ATOX1 include Menkes Disease and Wilson Disease. Among its related pathways are Cellular responses to stimuli and Innate Immune System. Gene Ontology (GO) annotations related to this gene include copper ion binding and copper-dependent protein …

Human antioxidant protein 1 (Atox1) is a small cytosolic protein with an essential role in copper homeostasis. Atox1 functions as a copper carrier facilitating copper transfer to the secretory pathway.

The present study with re-expression of nuclear-targeted Atox1 in Atox1-/-cells strongly suggests that it is nuclear Atox1 that plays an essential role in copper-stimulated increases in cyclin D1 expression and cell proliferation.

2025年2月8日 · copper transport protein ATOX1, ATX1 antioxidant protein 1 homolog, metal transport protein ATX1. GeneRIFs: Gene References Into Functions. Atox1-cyclin D1 loop activity is critical for survival of tumor cells with inactivated TP53.

ATOX1 is responsible for delivering copper to copper-dependent enzymes involved in antioxidant defense and extracellular matrix remodeling. ATOX1-mediated dysregulation of copper homeostasis is associated with increased oxidative stress and altered cellular behavior, potentially leading to cancer development .

2024年3月14日 · Copper is also transported to the trans-Golgi by antioxidant 1 copper chaperone (ATOX1). Copper can be delivered by CCS to the nucleus, where it activates transcription factors such as hypoxia...

2024年12月10日 · Title: Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro. Copper enhances genotoxic drug resistance via ATOX1 activated DNA damage repair.

2008年4月4日 · Here we show that antioxidant-1 (Atox1), previously appreciated as a copper chaperone, represents a novel copper-dependent transcription factor that mediates copper-induced cell proliferation. Stimulation of mouse embryonic fibroblasts (MEFs) with copper markedly increased cell proliferation, cyclin D1 expression, and entry into S phase, which ...

2023年9月13日 · This review collects data on the antioxidant role of ATOX1, the gene role’s in the angiogenesis regulation and cancer cell proliferation, and its role in the pathogenesis of copper-induced diseases—Wilson–Konovalov disease and Menkes disease.

2017年11月11日 · We show that the copper chaperone Atox1, which delivers copper to ATP7B, and the group of the first three metal-binding domains (MBD1–3) are central to the activity regulation of ATP7B. Atox1–Cu binding to ATP7B changes domain dynamics and interactions within the MBD1–3 group and activates ATP hydrolysis.