Mechanisms of Plaque Formation and Rupture
2014年6月6日 · Atherosclerosis causes clinical disease through luminal narrowing or by precipitating thrombi that obstruct blood flow to the heart (coronary heart disease), brain (ischemic stroke), or lower extremities (peripheral vascular disease).
Atherosclerosis: Symptoms, Causes & Treatment - Cleveland Clinic
2024年2月15日 · Plaque rupture or erosion. In this stage, a blood clot forms in your artery due to plaque rupture or plaque erosion. Plaque rupture happens when the fibrous cap that covers the plaque breaks open.
Atherosclerotic Plaque Rupture | Arteriosclerosis, Thrombosis, …
2016年8月1日 · In the case of atherosclerosis, over time multiple subclinical cellular events result in the development of unstable, vulnerable atherosclerotic lesions, which leads to the rupture of atherosclerotic plaques, culminating in the often catastrophic clinical manifestation of myocardial infarction or ischemic stroke.
Mechanisms of Plaque Rupture - Mechanisms of Vascular …
Atherosclerosis begins in childhood, but it takes decades for atherosclerosis to evolve into the mature plaques responsible for the onset of ischaemic symptoms.
Plaque Rupture in Coronary Atherosclerosis Is Associated With …
Plaque rupture occurs when intraplaque stress exceeds the material strength of the overlying fibrous cap; increased plaque structural stress (PSS) is therefore a potential mechanism that determines rupture of a higher risk lesion.
Pathophysiology of Atherosclerosis - PMC
This review focuses on the different stages of atherosclerosis development, ranging from endothelial dysfunction to plaque rupture. In addition, the post-transcriptional regulation and modulation of atheroma plaque by microRNAs and lncRNAs, the role of microbiota, and the importance of sex as a crucial risk factor in atherosclerosis are covered ...
Atherosclerosis - StatPearls - NCBI Bookshelf
2020年9月10日 · Advancing Atheroma: Thin-Cap Fibroatheroma and Its Rupture. Advancing atheroma appear at about age 55 to 65 years. Plaque rupture, for example, vulnerable plaques, are dictated by a thin, fibrous cap with low, smooth, muscle cell (SMC) density, abundant lipid, and macrophages, and enriched in tissue factor in the cells.
The Relation between Atherosclerosis Plaque Composition and Plaque Rupture
Maximum stress that atherosclerosis plaque can burden before its rupture depends on fibrous cap thickness, lipid core, calcification, and artery stenosis. When atherosclerotic plaque ruptures, the blood would be in contact with coagulation factors.
Differences in Stable and Unstable Atherosclerotic Plaque
2024年6月26日 · Acute plaque rupture with luminal thrombosis is the major cause of myocardial infarction and sudden death. Because of the histological diversity of atherosclerotic lesions, 1 it is essential to simplify plaques into unstable and stable plaques to accurately understand and provide better clinical context for this devastating disease.
Atherosclerosis - Nature Reviews Disease Primers
2019年8月16日 · Plaque rupture. Rupture of atherosclerotic plaques is the most common trigger of acute thrombosis of coronary arteries that causes myocardial infarction 64,65. Atherosclerotic plaques that have...