Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene. [5] ATG13 is an autophagy factor required for phagosome formation. ATG13 is a target of the TOR kinase signaling pathway that regulates autophagy through phosphorylation of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 ...

Dec 24, 2024 · ATG13 (Autophagy Related 13) is a Protein Coding gene. Diseases associated with ATG13 include Prostate Cancer and Liver Carcinoma In Situ. Among its related pathways are Autophagy and Alzheimer's disease and miRNA effects. Gene Ontology (GO) annotations related to this gene include protein kinase binding.

Ubiquitous expression in testis (RPKM 17.3), brain (RPKM 12.2) and 25 other tissues. 该基因编码的蛋白质是自噬因子和 TOR 激酶信号通路的靶标。 编码的蛋白质对于自噬体形成和线粒体自噬至关重要。 [RefSeq 提供，2016 年 10 月] The protein encoded by this gene is an Autophagy factor and a target of the TOR kinase signaling pathway.

Elevated ATG13 in serum of patients with ME/CFS stimulates oxidative stress response in microglial cells via activation of receptor for advanced glycation end products (RAGE). Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas.

In vertebrates, the orthologous ULK1 kinase complex contains the Ser/Thr kinase ULK1 and the accessory proteins ATG13, RB1CC1, and ATG101. Among these components, Atg1/ULK1 have gained major attention in the past, i.e., for the identification of upstream regulatory kinases, the characterization of downstream substrates controlling the ...

Mar 4, 2017 · Atg13 is an essential subunit of the Atg1 autophagy initiation complex in yeast and its mammalian counterpart, ATG13, is indispensable for autophagy induction by the ULK1 complex. The N terminus of the protein folds into a HORMA domain, an architecture that has been revealed by crystallography.

The process is induced by various nutrient-responsive signaling cascades converging on the Autophagy-Related1 (ATG1)/ATG13 kinase complex. Here, we describe the ATG1/13 complex in Arabidopsis thaliana and show that it is both a regulator and a target of autophagy.

Atg13 is an essential subunit of the Atg1 autophagy initiation complex in yeast and its mammalian counterpart, ATG13, is indispensable for autophagy induction by the ULK1 complex.

Jan 25, 2017 · Atg13是酵母中Atg1自噬起始复合物的必需亚基，其哺乳动物对应物ATG13对于ULK1复合物的自噬诱导是必不可少的。 蛋白质的N端折叠成一个HORMA结构域，该结构已通过晶体学揭示。

Jun 15, 2020 · 自噬是真核生物中发现的保守降解机制，主要有自噬相关蛋白（atg）执行自噬过程，ulk1/atg13是最上游的自噬起始复合物。 细胞周期由间期和分裂期组成；一般而言，非同步化细胞中细胞间期和分裂期时间比例是95%、5%。

Atg13, via an intrinsically disordered region, provides a flexible linkage between two Atg17 molecules to mediate multimeric Atg1 complex self-assembly for PAS organization.

Atg13 -deficient embryos show growth retardation and myocardial growth defects. In cultured fibroblasts, Atg13 deficiency blocks autophagosome formation at an upstream step.

The Atg1-Atg13 complex, localizing to the PAS independently of the PtdIns 3-kinase complex I , initiates retrieval of Atg9 by inducing its interaction with Atg18 and Atg2. The association of Atg2 to the PAS is probably achieved by simultaneously binding Atg9 and Atg18 ( Wang et al., 2001 ; P.E.S. and D.J.K., unpublished data).

Jun 9, 2020 · Unc-51-like autophagy activating kinase 1 (ULK1)–autophagy-related 13 (ATG13) is the most upstream autophagy initiation complex that is phosphorylated by mammalian target-of-rapamycin complex 1 (mTORC1) and AMP-activated protein kinase (AMPK) to induce autophagy in asynchronous conditions.

Sep 5, 2023 · Atg13-mediated ULK complex initiated autophagy and promoted formation of autophagosome that activated the NF-κB/ NLRP3 signaling pathway in BEAS-2B cells. The essential insights of this research revealed that locus-specific m6A methylation of Atg13 mRNA contributed to regulate epithelial inflammation-driven pulmonary fibrosis provoked by PM2.5 ...

Dec 7, 2015 · Atg13-deficient embryos show growth retardation and myocardial growth defects. In cultured fibroblasts, Atg13 deficiency blocks autophagosome formation at an upstream step. In addition, sensitivity to tumor necrosis factor alpha (TNF-α)-induced apoptosis is enhanced by deletion of Atg13 or FIP200, but not by other Atg proteins, as well as by ...

Macroautophagy/autophagy is an evolutionarily conserved cellular process whose induction is regulated by the ULK1 protein kinase complex. The subunit ATG13 functions as an adaptor protein by recruiting ULK1, RB1CC1 and ATG101 to a core ULK1 complex. Furthermore, ATG13 directly binds both phospholipids and members of the Atg8 family.

Feb 10, 2017 · Atg13 is an essential subunit of the Atg1 autophagy initiation complex in yeast and its mammalian counterpart, ATG13, is indispensable for autophagy induction by the ULK1 complex. The N terminus of the protein folds into a HORMA domain, an architecture that has been revealed by crystallography.

Macroautophagy/autophagy is an evolutionarily conserved cellular process whose induction is regulated by the ULK1 protein kinase complex. The subunit ATG13 functions as an adaptor protein by recruiting ULK1, RB1CC1 and ATG101 to a core ULK1 complex. Furthermore, ATG13 directly binds both phospholipids and members of the Atg8 family.

Western blot analysis of ATG13. Total cell lysates (30 μg) from C2C12, H9c2, HAP-1, HeLa, HepG2, and HT-1080 cell lines were loaded and separated by SDS-PAGE. The blot was incubated with ATG13 Recombinant Monoclonal Antibody (Product # MA5-56979) at a 1:5,000 dilution and HRP-conjugated goat anti-rabbit secondary antibody at a 1:20,000 ...