Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene. [5] ATG13 is an autophagy factor required for phagosome formation.

2024年12月24日 · ATG13 (Autophagy Related 13) is a Protein Coding gene. Diseases associated with ATG13 include Prostate Cancer and Liver Carcinoma In Situ. Among its related pathways are Autophagy and Alzheimer's disease and miRNA effects. Gene Ontology (GO) annotations related to this gene include protein kinase binding.

Atg13 is an essential subunit of the Atg1 autophagy initiation complex in yeast and its mammalian counterpart, ATG13, is indispensable for autophagy induction by the ULK1 complex. The N terminus of the protein folds into a HORMA domain, an ...

Here, we describe the ATG1/13 complex in Arabidopsis thaliana and show that it is both a regulator and a target of autophagy. Plants missing ATG13 are hypersensitive to nutrient limitations and senesce prematurely similar to mutants lacking …

Furthermore, recent data have identified additional binding partners of Atg13/ATG13 besides the components of the Atg1/ULK1 complex, e.g., Atg8 family proteins or acidic phospholipids. Therefore, in this review we will center the spotlight on Atg13/ATG13 and summarize the role that Atg13/ATG13 assumes in the autophagy stage play.

The ability to interact with Atg1/ULK1 and Atg17/RB1CC1 is a central feature of Atg13/ATG13. Accordingly, Atg13/ATG13 is an important component of the autophagic machinery, and this is confirmed by several Atg13/ATG13 knockdown, loss-of-function, and knockout studies (summarized in Table 3). However, future studies will have to reveal whether ...

Elevated ATG13 in serum of patients with ME/CFS stimulates oxidative stress response in microglial cells via activation of receptor for advanced glycation end products (RAGE). Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas.

2020年5月26日 · Here, we highlight past and recent key findings on the function of ATG proteins related to autophagosome biogenesis and consider how ATG proteins control this dynamic membrane formation event...

These results indicated that ATG13 may be a positive regulator of the type I interferon response. Next, we co‐transfected ATG13 with signalling proteins involved in innate antiviral response and determined the activation of ISRE or nuclear factor kappa B (NF‐κB) promoters.

Atg13, via an intrinsically disordered region, provides a flexible linkage between two Atg17 molecules to mediate multimeric Atg1 complex self-assembly for PAS organization.